Table 2 Radiotherapy and dosimetric parameters
From: Multifocal high-grade glioma radiotherapy safety and efficacy
Pat | RT Plan | Dose (Gy) | Conc. Ctx | Adj. Ctx | GTV Sum (ccm) | PTV (ccm) | Brain (ccm) | PTV/brain ratio (%) | Mean brain dose (Gy) | D2 Brain (Gy) | V30 Brain (%) | V45 Brain (%) | Treatment at progression |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 3D CRT | 60 | TMZ | TMZ | 67.2 | 654.1 | 1554.9 | 42.1 | 44.3 | 61.5 | 74.1 | 64.1 | BSC |
2 | 3D CRT | 60 | TMZ | TMZ | 20.1 | 446.8 | 1252.7 | 35.7 | 37.9 | 61.5 | 62.3 | 53.5 | BSC |
3 | 3D CRT | 59.4 | TMZ | none | 48.6 | 573.8 | 1464.5 | 39.2 | 38.3 | 60.2 | 68.4 | 53.5 | BSC |
4 | 3D CRT | 59.4 | TMZ | TMZ | 39.8 | 544.3 | 1435.1 | 37.9 | 37.4 | 62.1 | 58.3 | 49 | BSC |
5 | 3D CRT | 59.4 | TMZ | none | 10 | 567.3 | 1179 | 48.1 | 37.6 | 60.1 | 61.6 | 48.7 | BSC |
6 | 3D CRT | 60 | TMZ | TMZ | 16.7 | 435.5 | 1388.8 | 31.4 | 37.2 | 61.3 | 54.4 | 41.8 | BSC |
7 | IMRT | 60 | TMZ | TMZ | 58 | 833.8 | 1466.1 | 56.9 | 43 | 60.7 | 79.3 | 53.8 | BSC |
8 | IMRT | 60 | TMZ | none | 113.6 | 578.3 | 1372.5 | 42.1 | 42.5 | 62.7 | 68.4 | 46.7 | BEV/IRI |
9 | IMRT | 60 | TMZ | TMZ | 21.9 | 415.9 | 1410.9 | 29.5 | 40.1 | 62.5 | 66 | 49.2 | BSC |
10 | IMRT | 55 | none | none | 24.9 | 516.1 | 1355.4 | 38.1 | 31.5 | 57.4 | 52.5 | 32.2 | BEV/IRI |
11 | VMAT | 60 | TMZ | none | 89.3 | 349.5 | 1458.7 | 24 | 36.8 | 60.4 | 63.9 | 39.2 | BSC |
12 | VMAT | 50 | BEV | BEV | 303.9 | 888.5 | 1406.5 | 63.2 | 36.4 | 51.2 | 79.7 | 14.9 | BSC |
13 | VMAT | 60 | TMZ | none | 16.9 | 333.2 | 1285.2 | 25.9 | 32.5 | 61.8 | 56.1 | 34.2 | BSC |
14 | VMAT | 60 | TMZ | TMZ | 3.6 | 290 | 1241.4 | 23.4 | 30.8 | 62 | 40.8 | 29.2 | ReRT + TMZ |
15 | VMAT | 60 | TMZ | CeTeG | 13.3 | 192.6 | 1451.2 | 13.3 | 27.9 | 61.5 | 34.3 | 23.7 | NA |
16 | 3D CRT | 60 | TMZ | none | 23.7 | 373.25 | 1175.1 | 31.8 | 39.7 | 61.7 | 61.5 | 48.9 | BSC |
17 | VMAT | 60 | CeTeG | CeTeG | 27.1 | 203.4 | 1599.6 | 12.7 | 25.3 | 61.7 | 33 | 21 | TMZ ReRT GLIAA |
18 | VMAT | 60 | TMZ | TMZ | 39.6 | 400.8 | 1187.1 | 33.8 | 36.1 | 61.8 | 56.5 | 39.6 | BSC |
19 | VMAT | 60 | TMZ | TMZ | 27.4 | 375.6 | 1410.8 | 26.6 | 31.9 | 62.1 | 44.6 | 33.6 | BSC |
20 | VMAT | 60 | none | none | 12.5 | 161.6 | 1342.1 | 12 | 31.4 | 61.4 | 42.1 | 21.2 | BSC |
Median | NA | 60 | NA | NA | 26 | 425.7 | 1397.65 | 32.8 | 37 | 61.5 | 59.9 | 40.7 | NA |