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Table 2 Summary of univariate analysis of prognostic factors

From: Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities

Endpoint

Variable

HR

95% CI for HR

P valuea

OS

Primary tumour site

  

0.029

 

Nasal cavity

1.749

(1.096, 2.791)

 
 

Paranasal sinus

3.438

(2.974, 6.525)

 
 

Oral cavity

2.032

(1.222, 3.378)

 
 

Others(reference)

1

  
 

Reoperation

0.653

(0.477, 0.894)

0.008

 

T classification

  

 < 0.001

 

T3(reference)

1

  
 

T4a

3.263

(2.336, 4.560)

 
 

T4b

3.407

(1.776, 6.536)

 
 

Node classification

1.641

(1.181, 2.281)

0.003

 

Immunologic/targeted therapy

0.671

(0.473, 0.952)

0.025

DMFS

Primary tumour site

  

0.002

 

Nasal cavity

1.749

(1.096, 2.791)

 
 

Paranasal sinus

3.438

(1.811, 6.525)

 
 

Oral cavity

2.032

(1.222, 3.378)

 
 

Others(reference)

1

  
 

Reoperation

0.721

(0.539, 0.964)

0.027

 

Irradiation technique

1.723

(0.987, 3.010)

0.056

 

T classification

  

 < 0.001

 

T3(reference)

1

  
 

T4a

2.897

(2.121, 3.957)

 
 

T4b

4.282

(2.279, 8.044)

 
 

N classification

1.725

(1.267, 2.349)

0.001

DFS

Primary tumour site

  

0.001

 

Nasal cavity

1.584

(1.020, 2.459)

 
 

Paranasal sinus

2.880

(1.576, 5.262)

 
 

Oral cavity

2.260

(1.405, 3.636)

 
 

Others(reference)

1

  
 

Irradiation technique

1.943

(1.125, 3.358)

0.017

 

T classification

  

 < 0.001

 

T3(reference)

1

  
 

T4a

2.363

(1.772, 3.152)

 
 

T4b

2.848

(1.539, 5.270)

 
 

Node classification

1.775

(1.315, 2.396)

 < 0.001

 

Smoke

0.754

(0.559, 1.015)

0.063

 

Surgery

0.592

(0.355, 0.989)

0.045

LRRFS

Primary tumour site

  

 < 0.001

 

Nasal cavity

1.878

(1.177, 2.995)

 
 

Paranasal sinus

3.848

(2.068, 7.161)

 
 

Oral cavity

2.602

(1.579, 4.287)

 
 

Others(reference)

1

  
 

Irradiation technique

1.610

(0.935, 2.770)

0.086

 

T classification

  

 < 0.001

 

T3(reference)

1

  
 

T4a

2.148

(1.610, 2.864)

 
 

T4b

2.705

(1.463, 5.003)

 
 

Node classification

1.712

(1.263, 2.320)

0.001

 

Surgery

0.581

(0.348, 0.971)

0.038

  1. aStatistically significant results are shown in bold. *P values < 0.05 are highlighted in bold
  2. OS, overall survival; DMFS, distant metastasis-free survival; DFS: disease-free survival probability; LRRFS, local regional relapse free survival; HR, hazard ratio; CI, confidence interval
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Radiation Oncology

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