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Table 2 Summary of univariate analysis of prognostic factors

From: Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities

Endpoint Variable HR 95% CI for HR P valuea
OS Primary tumour site    0.029
  Nasal cavity 1.749 (1.096, 2.791)  
  Paranasal sinus 3.438 (2.974, 6.525)  
  Oral cavity 2.032 (1.222, 3.378)  
  Others(reference) 1   
  Reoperation 0.653 (0.477, 0.894) 0.008
  T classification     < 0.001
  T3(reference) 1   
  T4a 3.263 (2.336, 4.560)  
  T4b 3.407 (1.776, 6.536)  
  Node classification 1.641 (1.181, 2.281) 0.003
  Immunologic/targeted therapy 0.671 (0.473, 0.952) 0.025
DMFS Primary tumour site    0.002
  Nasal cavity 1.749 (1.096, 2.791)  
  Paranasal sinus 3.438 (1.811, 6.525)  
  Oral cavity 2.032 (1.222, 3.378)  
  Others(reference) 1   
  Reoperation 0.721 (0.539, 0.964) 0.027
  Irradiation technique 1.723 (0.987, 3.010) 0.056
  T classification     < 0.001
  T3(reference) 1   
  T4a 2.897 (2.121, 3.957)  
  T4b 4.282 (2.279, 8.044)  
  N classification 1.725 (1.267, 2.349) 0.001
DFS Primary tumour site    0.001
  Nasal cavity 1.584 (1.020, 2.459)  
  Paranasal sinus 2.880 (1.576, 5.262)  
  Oral cavity 2.260 (1.405, 3.636)  
  Others(reference) 1   
  Irradiation technique 1.943 (1.125, 3.358) 0.017
  T classification     < 0.001
  T3(reference) 1   
  T4a 2.363 (1.772, 3.152)  
  T4b 2.848 (1.539, 5.270)  
  Node classification 1.775 (1.315, 2.396)  < 0.001
  Smoke 0.754 (0.559, 1.015) 0.063
  Surgery 0.592 (0.355, 0.989) 0.045
LRRFS Primary tumour site     < 0.001
  Nasal cavity 1.878 (1.177, 2.995)  
  Paranasal sinus 3.848 (2.068, 7.161)  
  Oral cavity 2.602 (1.579, 4.287)  
  Others(reference) 1   
  Irradiation technique 1.610 (0.935, 2.770) 0.086
  T classification     < 0.001
  T3(reference) 1   
  T4a 2.148 (1.610, 2.864)  
  T4b 2.705 (1.463, 5.003)  
  Node classification 1.712 (1.263, 2.320) 0.001
  Surgery 0.581 (0.348, 0.971) 0.038
  1. aStatistically significant results are shown in bold. *P values < 0.05 are highlighted in bold
  2. OS, overall survival; DMFS, distant metastasis-free survival; DFS: disease-free survival probability; LRRFS, local regional relapse free survival; HR, hazard ratio; CI, confidence interval