Functional and mutational analysis after radiation and cetuximab treatment on prostate carcinoma cell line DU145

Radiation Oncology

Table 2 Frequency of detected nuclein base- and amino acid change in the TP53-gene in cell line DU145 and A431 respective ± cetuximab (l)^†, ^†long-term treatment

Zelllinie	Gene	Amino Acid Change	Variant Type	Nucleotide Change	Variant Frequency
DU145	TP53	p.Val274Phe	missense variant	c.820G > T	0.641
DU145 + Cetuximab (l)^†	TP53	p.Val274Phe	missense variant	c.820G > T	0.652
A431	TP53	p.Arg273His	missense variant	c.818G > A	0.994
A431 + Cetuximab (l)^†	TP53	p.Arg273His	missense variant	c.818G > A	0.996

ISSN: 1748-717X