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Table 2 Frequency of detected nuclein base- and amino acid change in the TP53-gene in cell line DU145 and A431 respective ± cetuximab (l), long-term treatment

From: Functional and mutational analysis after radiation and cetuximab treatment on prostate carcinoma cell line DU145

Zelllinie Gene Amino Acid Change Variant Type Nucleotide Change Variant Frequency
DU145 TP53 p.Val274Phe missense variant c.820G > T 0.641
DU145 + Cetuximab (l) TP53 p.Val274Phe missense variant c.820G > T 0.652
A431 TP53 p.Arg273His missense variant c.818G > A 0.994
A431 + Cetuximab (l) TP53 p.Arg273His missense variant c.818G > A 0.996