Table 3 Published dose constraints that are plotted in the DVH Risk Map in Fig. 2 of the paper

1

5

14.4

0

33

[43, 44]

RTOG 0631, limit is for sacral plexus

1

0.03

18

0

33

[43, 44]

RTOG 0631, limit is for sacral plexus

1

3

14

[43, 44]

RTOG 0631

1

3

14

1

33

[44]

One G3 possible radiosurgery-related AE (neck pain)

1

0.03

17.5

[43, 44]

RTOG 0631

1

0.03

17.5

1

33

[44]

One G3 possible radiosurgery-related AE (neck pain)

1

17.5

[45, 46]

RTOG 0915, TG101

1

16

[47]

Also for sacral plexus

1

3

14.4

[47]

Also for sacral plexus

1

3

14

[45, 46]

RTOG 0915, TG101

1

10

0

23

[48, 49]

1

8

0

32

[50]

3

56.7

[51]

RTOG 1021 acceptable deviation

3

27

[52]

3

26

7

37

[1, 53]

100 Gy BED3, 14% risk, 46% above, 8% below

3

24

[46, 47, 51, 54,55,56,57,58,59,60,61,62,63,64,65]

RTOG 0618, 1021, Accuray STARS, Also for sacral plexus, TG101

3

24

0

10

[56]

3

24

0

38

[52, 62]

3

24

0

79

[63]

3

24

0

70

[65]

3

3

22.5

[47]

Also for sacral plexus

3

3

20.4

[46, 51]

TG101, RTOG 1021

4

42.5

1

1

27

[66]

20% of brachial plexus > 40gy in one pt who had G3 AE

4

20%

40

1

1

27

[66]

20% of brachial plexus > 40gy in one pt who had G3 AE

4

40

1

27

[53, 59, 66, 67]

Accuray STARS, 1 AE at 40 Gy described in Chang 2015

4

1

35

27

[59, 66]

Accuray STARS

4

10

30

27

[59, 66]

Accuray STARS

4

26

[1, 53]

This limit has been attributed to 3–4 fractions

4

35

3

9

82

[68]

4

0.2

30

3

7

82

[68]

4

32

[52]

4

27.2

[45, 69]

RTOG 0915

4

3

23.6

[45]

RTOG 0915

5

45

1

12

[63]

5

35

[52]

5

1

40

50

[70]

5

32

[47, 71]

RTOG 0813, QOD, Also for sacral plexus

5

30.5

[46]

TG101

5

30

[72]

5

29.6

[69]

5

3

30

[47, 71]

RTOG 0813, QOD, Also for sacral plexus

5

3

27

[46]

TG101

7

35

[72]

8

37

0

46

[73]