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Table 1 Patient and treatment characteristics

From: Radiomics for prediction of radiation-induced lung injury and oncologic outcome after robotic stereotactic body radiotherapy of lung cancer: results from two independent institutions

 

Training set

 

Test set

 
 

(n = 110)

 

(n = 71)

 

Age (median/range)

73y (50–94 year)

 

75y (48–88 year)

 

Gender (male/female)

58/52 (53%/47%)

 

47/24 (66%/34%)

 

Tumor diameter (median/range)

2.2 cm (0.8–6.6 cm)*

 

2.6 cm (1.1–6.0 cm)#

 

Tumor stage (UICC8), T1/T2

89/21 (81%/19%)

 

45/26 (63%/37%)

 

Pathological confirmation (Yes/No)

91/19 (83%/17%)

 

55/16 (77%/23%)

 

Mediastinal staging

    

 CT only

18 (16%)

 

5 (7%)

 

 CT + PET

52 (47%)

 

33 (47%)

 

 CT + EBUS

18 (16%)

 

16 (23%)

 

 CT + EBUS + PET

18 (16%)

 

17 (24%)

 

 CT + mediastinoscopy

3 (3%)

 

 

 CT + PET + mediastinoscopy

1 (1%)

 

 

Histology

    

 Adenocarcinoma

37 (34%)

 

23 (32%)

 

 Squamous cell

42 (38%)

 

28 (39%)

 

 Other

12 (11%)

 

4 ( 6%)

 

 Unknown

19 (17%)

 

16 (23%)

 

Fractionation scheme

    

Number of fractions

Dose per fraction

n Pat

Dose per fraction

n Pat

 1

25 Gy

5 (5%)

26–27 Gy

2 (3%)

 3

17 Gy

45 (41%)

13–18 Gy

65 (90%)§

 5

11 Gy

43 (39%)

10–11 Gy

3 (6%)

 8

7.5 Gy

17 (16%)

6.0 Gy

1 (1%)

Doses to GTV, PTV and lung (median/ range)

    

 GTV Dmax

84.6 (28.2–95.2) Gy

 

70.9 (41.5–84.6) Gy

 

 GTV Dmean

71.6 (26.2–84.0) Gy

 

62.7 (37.9–72.5) Gy

 

 GTV D95%

61.9 (21.8–75.9) Gy

 

53.8 (33.0–64.6) Gy

 

 PTV D95%

54.0 (19.0–67.1) Gy

 

45.3 (25.2–55.2) Gy

 

 Lung D1ml

65.6 (23.6–81.0) Gy

 

55.5 (37.7–71.6) Gy

 

 Lung D10ml

52.1 (15.8–78.9) Gy

 

47.5 (25.8–66.9) Gy

 

 Lung D50ml

31.3 (6.9–77.7) Gy

 

31.6 (11.2–51.9) Gy

 

 Lung D100ml

20.5 (4.5–77.0) Gy

 

20.5 (6.6–43.0) Gy

 

GTV-PTV margin

3–4 mm

 

3–5 mm

 

Tracking Mode (Fiducials/XSightLung)

15/95 (14%/86%)

 

6/65 (9%/91%)

 
  1. *1 pt. > 5 cm
  2. #3 pts. > 5 cm
  3. §1 pt. 4 × 10 Gy