Clinical outcomes of extensive-stage small cell lung cancer patients treated with thoracic radiotherapy at different times and fractionations

Table 3 Univariate and multivariate survival analyses of the prognostic factors for OS in patients receiving TRT

Variables	Univariate	Multivariate
Variables	p value	HR(95%CI)	p value
Age, y (≥ 60 vs < 60)	0.191	–	–
Sex (Male vs Female)	0.073	–	–
ECOG PS score (≤ 1 vs > 1)	0.013	0.52 (0.31,0.88)	0.013
Smoking index (< 400 vs ≥ 400)	0.014	1.56 (1.16,2.11)	0.003
Number of metastases (≤ 2 vs > 2)	0.006	1.01 (0.61,1.68)	0.962
Metastatic organs (Single vs Multiple)	< 0.001	1.52 (0.97,2.36)	0.065
Brain metastasis (yes vs no)	0.299	–	–
Liver metastasis (yes vs no)	< 0.001	1.71 (1.22,2.41)	0.002
Bone metastasis (yes vs no)	0.011	1.13 (0.82,1.56)	0.455
Weight loss (yes vs no)	0.021	1.60 (1.04,2.46)	0.034
PCI (yes vs no)	0.018	0.48 (0.24,0.96)	0.039

ECOG PS, Eastern Cooperative Oncology Group performance status; PCI, Prophylactic cranial irradiation; OS, overall survival; TRT, thoracic radiotherapy; HR, hazard ratio; CI, confidence interval

ISSN: 1748-717X