Clinical outcomes of extensive-stage small cell lung cancer patients treated with thoracic radiotherapy at different times and fractionations

Table 1 Clinical characteristics of ES-SCLC patients based on the radiation time

Variables		≤ 2cycles	3-4cycles	5-6cycles	> 6 cycles	p value
Age, y	< 60	20	36	46	15
	≥ 60	21	42	46	18	0.950
Sex	Male	34	60	68	30
	Female	7	18	24	3	0.189
ECOG PS score	0–1	38	71	85	32
	2	3	7	7	1	0.487
Smoking index	≥ 400	20	47	38	15
	< 400	21	31	54	18	0.098
Metastatic organs	single	16	36	33	9
	Multiple	25	42	59	24	0.266
Number of metastases	≤ 2	11	18	16	4
	> 2	30	60	76	29	0.345
Brain metastasis	yes	25	46	55	22
	no	16	32	37	11	0.891
Liver metastasis	yes	9	21	35	7
	no	32	57	57	26	0.128
Bone metastasis	yes	18	22	38	20
	no	23	56	54	13	0.014
Weight loss	yes	4	8	14	5
	no	37	70	78	28	0.695
PCI	yes	3	6	5	2
	no	38	72	87	31	0.641
Radiation dose	≤ 50 Gy	27	50	60	22
	> 50 Gy	14	28	32	11	0.994

ES-SCLC, Extensive-stage small-cell lung cancer; ECOG PS, Eastern Cooperative Oncology Group performance status; PCI, Prophylactic cranial irradiation;

ISSN: 1748-717X