Fig. 6
From: Radiosensitization of breast cancer cells using AS1411 aptamer-conjugated gold nanoparticles
Radiosensitization in cancer stem-like cells enriched culture by AS1411/GNPs. a Picture of mammospheres obtained by the serum free culture of MCF-7 cells. b Real-time PCR data analysis demonstrating the increased expression of Oct4-a in mammospheres (***p < 0.001). c Gel electrophoreses of PCR products of OCT4-a expression in NT2 (positive control), monolayer (nSP) and mammosphere (SP) of MCF7 cells. d Viability of mammosphere cells treated with GNPs or AS1411/GNPs assessed by MTS assay following 24 h treatment with 12.5 mg/L Au. e Radiosensitization effect of the GNPs and AS1411/GNPs (12.5 mg/L) evaluated by clonogenic assay in cancer stem-like cells exposed to 4 MeV electron beams