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Table 3 Univariate analyses of local control (LC) and radiation necrosis-free survival (RNFS) of the 52 lesions

From: Stereotactic radiosurgery combined with targeted/ immunotherapy in patients with melanoma brain metastasis

VariableLesions (n)1 yr-LC (%)p-value1 yr-RNFS (%)p-value
Gender
 Male3395.7 84.3 
 Female1994.70.68894.40.165
PTV margin
 2 mm24100 86.3 
 3 mm2890.80.68890.00.407
Targeted/immunotherapy (TT/IT)
 Concurrent36100 90.0 
 No/ sequential1683.30.02382.10.935
Concurrent TT/IT before SRS
 Yes2191.4 78.3 
 No311000.19786.90.723
Concurrent TT/IT after SRS
 Yes36100 90.0 
 No1683.30.02382.10.935
BRAF
 BRAF wild type2791.5 91.6 
 BRAF mutation251000.18981.90.151
Melanoma-molGPA
 0.5–1.030 50.0 
 1.5–2.027100 90.9 
 2.5–3.016100 91.7 
 3.5–4.06100< 0.00183.30.147
V10
 12 ccm4094.6 94.4 
> 12 ccm121000.5537.0< 0.001
V12
 10 ccm4194.8 91.7 
> 10 ccm111000.58770.00.004