Correlation of dosimetric factors with the development of symptomatic radiation pneumonitis in stereotactic body radiotherapy

Table 3 Dose Volume Histogram Characteristics

Characteristic	No Radiation Pneumonitis (n = 85)	Symptomatic Radiation Pneumonitis (n = 8)	P value
Contralateral Lung V5, %
Median	3.1%	7.4%	0.05
Range	0.0–33.6%	4.2–53.4%	0.05
Ipsilateral Lung V30, %
Median	3.3%	9.6%	0.001
Range	0.8–11.6%	6.5–12.8%	0.001
Ipsilateral Lung V40, %
Median	2.1%	5.8%	0.003
Range	0.5–8.1%	3.6–8.8%	0.003
Total Lung V5, %
Median	14.7%	29.1%	0.001
Range	4.2–46.9%	18.2–56.9%	0.001
Total Lung V10, %
Median	8.4%	21.7%	0.001
Range	2.2–34.6%	10.8–38.4%	0.001
Total Lung V12.4, cm3
Median	223 cm3	372 cm3	0.004
Range	47–789 cm3	311–932 cm3	0.004
Total Lung V13.5, cm3
Median	195 cm3	333 cm3	0.004
Range	41–735 cm3	283–829 cm3	0.004
Total Lung V15, %
Median	5.4%	13.2%	0.001
Range	1.2–25.8%	7.8–18.8%	0.001
Total Lung V20, %
Median	3.4%	9.1%	0.001
Range	0.8–19.4%	5.3–12.8%
Total Lung V25, %
Median	2.4%	6.7%	0.001
Range	0.6–15.2%	3.6–9.6%	0.001
Total Lung V30, %
Median	1.8%	5.1%	0.002
Range	0.5–12.1%	2.4–7.4%	0.002
Total Lung V40, %
Median	1.1%	3.3%	0.003
Range	0.3–8.6%	1.1–4.7%	0.003

Abbreviations: V_dose is the percent of lung receiving greater than the “dose” (in Gy). Symptomatic Radiation Pneumonitis = RTOG G3+ or CTCAE G2+ RP
P-values from Wilcoxon Rank Sum tests, with all values Bonferroni adjusted. Bolded P-values indicate statistical significance

ISSN: 1748-717X