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Table 2 Patient’s characteristics according to radiation dose to internal mammary lymph node

From: Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer

Characteristics

Number of patients (%)

p-value

50–63.5 Gy 1)(n = 35)

63.6–70.4 Gy 1)(n = 49)

Age

≤ 40 years

15 (42.9%)

23 (46.9%)

0.825

>  40 years

20 (57.1%)

26 (53.1%)

Histologic grade

1–2

23 (71.9%)

22 (51.2%)

0.096

3

9 (28.1%)

21 (48.8%)

Subtypes

Non-TNBC

22 (62.9%)

32 (65.3%)

0.822

TNBC

13 (37.1%)

17 (34.7%)

cT stages

1–2

19 (54.3%)

28 (57.1%)

0.827

3–4

16 (45.7%)

21 (42.9%)

cN stages

2b or 3b

26 (74.3%)

37 (75.5%)

1.000

3c

9 (25.7%)

12 (24.5%)

FNABx for IMN

(−) or unknown

20 (57.1%)

24 (49.0%)

0.511

(+)

15 (42.9%)

25 (51.0%)

Extent of the IMN

Single ICS

13 (37.1%)

24 (49.0%)

0.373

Multiple ICS

22 (62.9%)

25 (51.0%)

IMN long diameter

<  1.0 cm

20 (57.1%)

22 (44.9%)

0.376

≥ 1.0 cm

15 (42.9%)

27 (55.1%)

Neoadjuvant chemotherapy

Not done

9 (25.7%)

9 (18.4%)

0.433

Done

26 (74.3%)

40 (81.6%)

Primary surgery

BCS

22 (62.9%)

18 (36.7%)

0.026

Mastectomy

13 (37.1%)

31 (63.3%)

Axillary surgery

ALND

30 (85.7%)

44 (89.8%)

0.735

SLNB

5 (14.3%)

5 (10.2%)

  1. 1)Radiotherapy dose was calculated using the biologically equivalent dose in 2 Gy fractions (EQD2) assuming the α/β ratio of 3.5 Gy
  2. Abbreviations: TNBC Triple-negative breast cancer, IMN Internal mammary node, FNABx Fine needle aspiration biopsy, ICS Intercostal space, BCS Breast conserving surgery, ALND Axillary lymph node dissection, SLNB Sentinel lymph node biopsy