Table 4 Estimates of the normal tissue complication probabilities according to the various models applied and endpoints considered. Results are shown as averages (with uncertainty expressed as 1 standard deviation) and median value (second line). The p value is relative to the Wilcoxon signed rank paired test

LAD

RR

Failure

1.41 ± 0.34

1.28 ± 0.39

0.13 ± 0.15

0.001

1.28

1.16

Left Ventricle

RR

Failure

1.26 ± 0.20

1.13 ± 0.18

0.13 ± 0.10

< 0.001

1.20

1.02

Heart

NTCP

Death (LQ)

0.16 ± 0.16

0.15 ± 0.13

0.02 ± 0.04

0.03

0.14

0.12

0.01

Lungs

NTCP

Pneum LQ

0.30 ± 0.37

0.14 ± 0.20

0.16 ± 0.21

< 0.001

0.17

0.05

0.09

NTCP

Pneum LKB

1.98 ± 1.04

1.34 ± 0.74

0.64 ± 0.47

< 0.001

1.77

1.09

0.55

NTCP

SymPneum LKB

4.61 ± 2.98

3.19 ± 2.27

1.42 ± 1.13

< 0.001

3.84

2.36

1.09

NTCP

SymFibr LKB

3.26 ± 1.79

2.75 ± 1.72

0.51 ± 0.45

< 0.001

2.75

2.22

0.38

Esophagus

NTCP

Esophagitis

2.61 ± 1.49

2.47 ± 1.52

0.15 ± 0.27

0.04

2.47

2.35

0.14

Composite 1

NTCP

–

12.92 ± 7.09

10.02 ± 5.83

2.90 ± 2.24

< 0.001

11.04

8.17

2.24

Composite 2

RR

–

2.68 ± 0.51

2.41 ± 0.55

0.26 ± 0.22

< 0.001

2.46

2.18

0.22