Table 1 Patient characteristics of 222 patients treated with pencil-beam scanning proton therapy
Parameter | Total N = 222 | Chordoma N = 151 | ChSa N = 71 | p value |
|---|---|---|---|---|
Age (years) | ||||
Mean (SD) | 40.8 (18.4) | 43.3 (18.1) | 35.6 (18.3) | 0.004 |
Gender | ||||
Female (%) | 105 (47.3) | 65 (43.0) | 40 (56.3) | 0.09 |
Male (%) | 117 (52.7) | 86 (57.0) | 31 (43.7) | |
Recurrent disease | ||||
No (%) | 171 (77) | 115 (76.2) | 56 (78.9) | 0.76 |
Yes (%) | 51 (23) | 36 (23.8) | 15 (21.1) | |
GTV (cc) | ||||
Mean (SD) | 35.7 (29.1) | 35.4 (27.5) | 36.1 (32.5) | 0.87 |
Brainstem compression | ||||
No (%) | 151 (68) | 100 (66.2) | 51 (71.8) | 0.62 |
Abutment (%) | 46 (20.7) | 34 (22.5) | 12 (16.9) | |
Yes (%) | 25 (11.3) | 17 (11.3) | 8 (11.3) | |
Optic apparatus compression | ||||
No (%) | 154 (69.4) | 113 (74.8) | 41 (57.7) | 0.03 |
Abutment (%) | 44 (19.8) | 26 (17.2) | 18 (25.4) | |
Yes (%) | 24 (10.8) | 12 (7.9) | 12 (16.9) | |
Any compression | ||||
No (%) | 109 (49.1) | 76 (50.3) | 33 (46.5) | 0.7 |
Yes (%) | 113 (50.9) | 75 (49.7) | 38 (53.5) | |
Surgery | ||||
Subtotal resection (%) | 215 (96.8) | 147 (97.3) | 68 (95.8) | 0.68 |
Complete resection (%) | 7 (3.2) | 4 (2.7) | 3 (4.2) | |
Number of surgeries | ||||
1 (%) | 101 (46.8) | 63 (43.4) | 38 (53.5) | 0.013 |
2 (%) | 78 (36.1) | 59 (40.7) | 19 (26.8) | |
3 (%) | 23 (12.0) | 14 (9.7) | 12 (16.9) | |
4 (%) | 6 (2.8) | 6 (4.1) | 0 (0) | |
5 (%) | 3 (1.4) | 3 (2.1) | 0 (0) | |
6 (%) | 2 (0.9) | 0 (0) | 2 (2.8) | |
Postoperative complications | ||||
No (%) | 154 (69.4) | 106 (70.2) | 48 (67.6) | 0.89 |
Yes (%) | 68 (30.6) | 45 (29.8) | 23 (32.4) | |