Efficacy and toxicity of re-irradiation for esophageal cancer patients with locoregional recurrence: a retrospective analysis

Table 6 Univariate and multivariate logistic analysis of risk factors of EP after re-RT

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p	HR	95% CI	p
Re-RT age (years)	1.114	0.610–2.036	0.725
Gender (n, %)	0.978	0.450–2.124	0.955
Smoking (n, %)	0.987	0.540–1.802	0.965
Alcohol consumption (n, %)	1.444	0.790–2.642	0.233
Primary tumor location (n, %)	0.673	0.355–1.278	0.227
Length, cm (n, %)	1.120	0.732–1.714	0.602
Macroscopic tumor type	1.210	0.881–1.662	0.240
Tumor differentiation (n, %)	1.127	0.703–1.805	0.620
T stage (n, %)	1.049	0.693–1.587	0.822
N stage (n, %)	0.908	0.597–1.382	0.652
Initial clinical/pathological stage (n, %)	1.113	0.738–1.679	0.610
Initial treatment	1.597	0.814–3.135	0.173
Pattern of recurrence (n, %)	1.360	0.911–2.031	0.133
Recurrence-free interval (months)	0.493	0.264–0.920	0.026	0.450	0.229–0.884	0.021
Re-RT dose (Gy)	0.788	0.430–1.447	0.443
Concurrent chemoradiotherapy	1.042	0.568–1.910	0.894
Total radiation dose (Gy)	0.742	0.404–1.361	0.335
Esophageal stenosis	3.250	1.739–6.074	0.000	2.665	1.359–5.225	0.004
Pain in the chest or/and back	2	0.752–4.557	0.180
Fat space between tumor and adjacent tissue disappeared	4.351	2.290–8.269	0.000	3.347	1.702–6.581	0.000
BMI	1.824	0.882–3.773	0.105
Hemoglobin (g/L)	0.634	0.345–1.166	0.143
Albumin (g/L)	0.786	0.422–1.463	0.447
White blood cells, × 10⁹/L	1.133	1.1011–1.270	0.032
Neutrophil, × 10⁹/L	1.121	0.995–1.263	0.059

ISSN: 1748-717X