Intensity-modulated radiation therapy versus three-dimensional conformal radiotherapy in head and neck squamous cell carcinoma: long-term and mature outcomes of a prospective randomized trial

Table 2 Site of second new primary, time-interval from index cancer and final clinical outcomes

Sr. No.	Arm	Primary site	Site of second new primary cancer	Time-interval from index cancer	Final clinical outcome
1	3D-CRT^a	Base of tongue	Buccal mucosa	13 months	Alive without disease
2	3D-CRT	Tonsil	Alveolus	72 months	Died of post-operative complications
3	3D-CRT	Pyriform sinus	Esophagus	19 months	Died of 2nd malignancy
4	3D-CRT	Glottic larynx	Esophagus	100 months	Died of 2nd malignancy
5	IMRT^b	Tonsil	Lung	19 months	Died of 2nd malignancy
6	IMRT	Pyriform sinus	Lung	27 months	Died of 2nd malignancy
7	IMRT	Supraglottic larynx	Urinary bladder	64 months	Cured of bladder cancer
7	IMRT	Supraglottic larynx	Tonsil (3rd primary)	72 months	Died of 3rd malignancy
8	IMRT	Base of tongue	Pyriform sinus	95 months	Died of 2nd malignancy
9	IMRT	Tonsil	Esophagus	56 months	Died of 2nd malignancy

^a3D-CRT three-dimensional conformal radiotherapy, ^b IMRT intensity-modulated radiation therapy

ISSN: 1748-717X