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Table 1 Patient characteristics

From: Phase I/IIa trial of androgen deprivation therapy, external beam radiotherapy, and stereotactic body radiotherapy boost for high-risk prostate cancer (ADEBAR)

Characteristic

Total (n = 26)

18 Gy (n = 12)

21 Gy (n = 14)

p-value

No. of patients (%)

Median age (range)

74 years (54–84)

74 years (66–80)

73 years (54–84)

0.860

T stage

   

0.297

 2b

1 (4)

0 (0)

1 (7)

 

 2c

2 (8)

0 (0)

2 (14)

 

 3a

14 (54)

7 (58)

7 (50)

 

 3b

5 (19)

3 (25)

2 (14)

 

 4

4 (15)

2 (17)

2 (14)

 

Grade group

   

0.462

 1

1 (4)

0 (0)

1 (7)

 

 2

2 (8)

2 (17)

0 (0)

 

 3

2 (8)

1 (8)

1 (7)

 

 4

8 (30)

4 (34)

4 (29)

 

 5

13 (50)

5 (42)

8 (57)

 

Initial PSA (ng/mL)

   

0.252

  < 10

5 (19)

1 (8)

4 (29)

 

 10–20

3 (12)

1 (8)

2 (14)

 

  > 20

18 (69)

10 (83)

8 (57)

 

Risk group

   

0.781

 High

1 (4)

0 (0)

1 (7)

 

 Very high

25 (96)

12 (100)

13 (93)

 

 Median duration of ADT, months (range)

25 (9–35)

26 (20–34)

25 (9–35)

0.742

Baseline OABSS (0–15)

   

0.781

 0–5 (mild)

23 (88)

11 (92)

12 (86)

 

 6–11 (moderate)

2 (8)

1 (8)

1 (7)

 

 12–15 (severe)

1 (4)

0 (0)

1 (7)

 

Baseline IPSS (0–35)

   

0.231

 1–7 (mild)

7 (27)

5 (42)

2 (14)

 

 8–19 (moderate)

16 (62)

6 (50)

10 (72)

 

 20–35 (severe)

3 (11)

1 (8)

2 (14)

 

Baseline QoL

   

0.036

 Delighted

5 (19)

5 (42)

0 (0)

 

 Pleased

5 (19)

1 (8)

4 (29)

 

 Mostly satisfied

4 (15)

2 (17)

2 (14)

 

 Mixed

7 (27)

2 (17)

5 (36)

 

 Mostly dissatisfied

3 (12)

1 (8)

2 (14)

 

 Unhappy

2 (8)

1 (8)

1 (7)

 

 Terrible

0 (0)

0 (0)

0 (0)

 
  1. ADT androgen deprivation therapy, IPSS International Prostate Symptom Score, OABSS overactive bladder symptom score, PSA prostate-specific antigen, QoL quality of life