Efficacy of orbital radiotherapy in moderate-to-severe active graves’ orbitopathy including long-lasting disease: a retrospective analysis

Table 2 Response to orbital radiotherapy

	Pre RT	3 months	6 months	P value
CAS	3.03 ± 1.87	1.81 ± 1.49	1.40 ± 1.44	< 0.001^a
Degree of proptosis (mm)	18.66 ± 3.35	17.90 ± 3.17	17.82 ± 3.14	< 0.001^a
MRD1 (mm)	4.08 ± 1.52	4.00 ± 1.41	3.79 ± 1.36	0.128^a
PFH (mm)	9.61 ± 2.23	9.47 ± 2.05	9.31 ± 2.00	0.184^a
Diplopia, Gorman score (number, %)
Absent	9 (14.5)	9 (14.5)	13 (21.0)	0.157^b
Intermittent	13 (21.0)	18 (29.0)	11 (17.7)
Inconstant	20 (32.3)	18 (29.0)	22 (35.5)
Constant	20 (32.3)	17 (27.4)	16 (25.8)
EOM movement ≤30°, number of patients (%)	34 (54.84)	29 (46.77)	25(40.32)	0.012^c
BCVA, logMAR	0.12 ± 0.20	0.04 ± 0.08	0.03 ± 0.08	< 0.001^a
Number of CON (%)	13 (20.97)	4 (6.45)	3 (4.84)	0.008^c
IOP (mmHg)	17.89 ± 3.26	17.82 ± 3.34	17.34 ± 3.65	0.127^a

CAS clinical activity score, MRD margin reflex distance, PFH palpebral fissure height, EOM extraocular muscle, VA visual acuity, CON compressive optic neuropathy, IOP intraocular pressure, ^a linear mixed effect model, ^b repeated measure proportional odd logistic regression, ^c generalized linear mixed effect model

ISSN: 1748-717X