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Table 1 Baseline patient characteristics by diagnostic category

From: Factors distinguishing invasive from pre-invasive adenocarcinoma presenting as pure ground glass pulmonary nodules

Variable

Total

(n = 659)

Pre-IAC

(n = 523)

IAC

(n = 136)

χ2

p

Sex

   

5.042

0.025

 Male

200 (30.3%)

148 (28.3%)

52 (38.2%)

  

 Female

459 (69.7%)

375 (71.7%)

84 (61.8%)

  

Age, years

   

40.540

< 0.001

  ≤ 55

325 (49.3%)

291 (55.6%)

34 (25.0%)

  

  > 55

334 (50.7%)

232 (44.4%)

102 (75.0%)

  

Smoking history

   

4.985

0.723

 Never

350 (53.1%)

283 (54.1%)

67 (49.3%)

  

 Current or former

309 (46.9%)

240 (45.9%)

69 (50.7%)

  

Symptoms

   

5.742

0.831

 Absent

480 (72.8%)

410 (78.4%)

70 (51.5%)

  

 Present

179 (27.2%)

113 (21.6%)

66 (48.5%)

  

Serum CEA, μg/L

   

.069

0.792

  < 5

652 (99.1%)

518 (99.2%)

134 (98.5%)

  

  ≥ 5

6 (0.9%)

4 (0.8%)

2 (1.5%)

  

Maximal diameter, cm

   

145.831

< 0.001

  ≤ 1

430 (65.2%)

401 (76.7%)

29 (21.3%)

  

  > 1

229 (34.8%)

122 (23.3%)

107 (78.7%)

  

Mean diameter, cm

   

188.727

< 0.001

  ≤ 1

475 (72.0%)

441 (84.3%)

34 (25.0%)

  

  > 1

184 (28.0%)

82 (15.7%)

102 (75.0%)

  

CT density, HU

   

21.374

< 0.001

  ≤ −600

344 (52.2%)

297 (56.8%)

47 (34.6%)

  

  > −600

315 (47.8%)

226 (43.2%)

89 (65.4%)

  

Pleural retraction

   

0.033

0.857

 Absent

633 (96.1%)

502 (96.0%)

131 (96.3%)

  

 Present

26 (3.9%)

21 (4.0%)

5 (3.7%)

  

Air bronchogram sign

   

.000

1.00

 Absent

647 (98.2%)

513 (98.1%)

134 (98.5%)

  

 Present

12 (1.8%)

10 (1.9%)

2 (1.5%)

  

Bubble lucency sign

   

0.278

0.598

 Absent

598 (90.7%)

473 (90.4%)

125 (91.9%)

  

 Present

61 (9.3%)

50 (9.6%)

11 (8.1%)

  

Spiculated sign

   

5.329

0.021

 Absent

560 (85.0%)

453 (86.6%)

107 (78.7%)

  

 Present

99 (15.0%)

70 (13.4%)

29 (21.3%)

  
  1. CEA carcinoembryonic antigen, CT computed tomography, HU Hounsfield units, IAC invasive adenocarcinoma