Table 2 Patient and tumour characteristics at re-irradiation. Abbreviations: VMAT - Volumetric modulated arc therapy, IMRT - Intensity modulated radiotherapy, PTV – planning target volume
Patient and treatment characteristics at re-irradiation | Number | Percent (range) |
|---|---|---|
Median age at end of re-irradiation (years) | 63 | (40–89) |
Median time between radiations (months) | 36 | (5–177) |
Performance status | ||
0 | 30 | 56 |
1 | 21 | 39 |
2 | 2 | 4 |
3 | 1 | 2 |
Tumour | ||
Local recurrence | 37 | 69 |
Secondary primary tumour | 17 | 31 |
Surgery before re-irradiation | ||
No | 32 | 59 |
Primary tumour | 11 | 20 |
Neck dissection | 8 | 15 |
Primary tumour and neck dissection | 3 | 6 |
Systemic medical treatment | ||
No | 41 | 76 |
Induction chemotherapy | 11 | 20 |
Concurrent chemotherapy (cisplatin) | 1 | 2 |
Concurrent cetuximab | 1 | 2 |
Radiotherapy technique at re-irradiation | ||
VMAT/IMRT | 45 | 83 |
VMAT/IMRT + brachytherapy | 3 | 6 |
3D conformal | 4 | 7 |
3D conformal + brachytherapy | 1 | 2 |
Brachytherapy | 1 | 2 |
Median re-irradiation dose (Gy) | 59 | (40–71) |
Median cumulative near max dose, D1cc (Gy) | 129 | (106–478) |
Median PTV at re-irradiation (cm3) | 145 | (13–668) |
Median re-treated volume, V100 (cm3) | 90 | (2–283) |