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Table 2 Ranges of the mean and one standard deviation (SD) of the dose volume histogram metrics over10 breathing phases in13 patients. All plans were prescribed by coverage according to ICRU 91

From: On the pitfalls of PTV in lung SBRT using type-B dose engine: an analysis of PTV and worst case scenario concepts for treatment plan optimization

 

PTVITV

PTVVH

WCSITV

WCSGTV

Range

Range

Range

Range

Mean (p-value)

SD (p-value)

Mean (p-value)

SD (p-value)

Mean (p-value)

SD (p-value)

Mean (p-value)

SD (p-value)

GTV

D98 (Gy)

55.7–62.5 (0.65)

0.3–1.0 (1.00)

55.5–62.2 (0.32)

0.2–1.8 (0.91)

55.0–61.5 (0.96)

0.3–1.1 (0.99)

54.8–60.5 (0.90)

0.2–1.2 (0.70)

D50 (Gy)

59.6–68.3 (0.38)

0.1–0.3 (1.00)

60.0–65.8 (0.58)

0.1–0.8 (1.00)

59.7–67.6 (0.82)

0.1–0.3 (1.00)

56.4–65.1 (0.84)

0.1–0.5 (1.00)

D2 (Gy)

64.9–73.6 (0.32)

0.0–0.6 (1.00)

61.2–70.5 (< 0.05)

0.0–0.7 (1.00)

61.6–72.5 (0.42)

0.0–0.3 (1.00)

60.6–70.6 (0.43)

0.0–0.5 (1.00)

Chest Wall

V30Gy (cm3)

9.3–73.1 (<  0.01)

0.7–5.3 (1.00)

2.8–39.9 (<  0.01)

0.8–4.8 (1.00)

1.6–31.6 (<  0.01)

0.3–4.4 (1.00)

1.8–29.9 (<  0.01)

0.3–3.8 (1.00)

Lung

V5Gy (cm3)

9.4–29.0 (0.06)

0.1–1.7 (0.91)

9.8–25.9 (<  0.05)

0.1–1.9 (1.00)

8.6–27.8 (< 0.05)

0.1–2.0 (1.00)

8.0–27.0 (0.09)

0.1–2.0 (1.00)

V20Gy (cm3)

3.6–15.1 (0.16)

0.1–3.7 (1.00)

3.8–14.8 (0.09)

0.1–1.3 (1.00)

3.3–14.8 (0.07)

0.1–1.2 (1.00)

3.0–14.0 (0.15)

0.1–1.3 (1.00)

MLD (Gy)

2.3–8.3 (<  0.01)

0.0–0.6 (1.00)

2.4–7.9 (<  0.01)

0.0–0.5 (1.00)

2.2–7.8 (<  0.01)

0.0–0.5 (1.00)

2.0–7.4 (<  0.01)

0.0–0.5 (1.00)

  1. Note: p values were obtainedfrom Freidman’s tests and Levene’s tests comparing the differences and the variances between ten breathing phases, respectively, in 13 patients per SBRT optimization method
  2. Abbreviations are the same as in Table 1