Patterns of recurrence in anal cancer: a detailed analysis

Radiation Oncology

Table 2 Common iliac and/or para-aortic (CI/PA) recurrence in different subgroups

	CI/PA recurrence^a
	No, n (%)	Yes, n (%)	P-value^b
T stage^c			0.045
T1–3	126 (98)	3 (2)
T4	33 (89)	4 (11)
N stage^c			0.44
0.	80 (98)	2 (2)
1.	79 (94)	5 (6)
Lymph node regions^dwith metastasis			0.02
< 3 regions	145 (97)	4 (3)
≥ 3 regions	14 (82)	3 (18)
Site of lymph node metastasis
Inguinal	58 (94)	4 (6)	0.43^e
Internal iliac	17 (90)	2 (10)	0.18^e
External iliac	17 (85)	3 (15)	0.04^e
Mesorectal^f or presacral	27 (93)	2 (7)	0.35^e
Distance from GTVN to iliac bifuration^g			0.32
< 5 cm	17 (90)	2 (10)
≥ 5 cm	62 (95)	3 (5)

^a4 patients with CI/PA metastasis at diagnosis excluded
^bFisher’s exact test, 2-sided
^cTNM8
^d7 regions: left inguinal; right inguinal; left internal iliac; right internal iliac; left external iliac; right external iliac; mesorectal/presacral
^eP-value for comparison with all other patients, including N0 patients
^fSuperior rectal included in mesorectal
^gDistance from superior border of the most cranial lymph node metastasis to the bifurcation of common iliac artery

ISSN: 1748-717X