Table 3 Multivariate Cox analyses of treatment methods for OS (n = 21,030)
TNM Stage | Treatments | Multivariate HR (95% CI) | P value |
|---|---|---|---|
T1-3N0M0 | 0.001 | ||
Only surgery | Reference | ||
Surgery + chemotherapy | 0.896(0.827–0.970) | 0.007 | |
Neoadjuvant radiotherapy | 1.171(1.019–1.347) | 0.027 | |
Adjuvant radiotherapy | 0.950(0.874–1.032) | 0.223 | |
T1-3N + M0 | < 0.001 | ||
Only surgery | Reference | ||
Surgery + chemotherapy | 0.686(0.649–0.726) | < 0.001 | |
Neoadjuvant radiotherapy | 0.751(0.635–0.887) | 0.001 | |
Adjuvant radiotherapy | 0.613(0.579–0.649) | < 0.001 | |
T4N0M0 | < 0.001 | ||
Only surgery | Reference | ||
Surgery + chemotherapy | 0.588(0.424–0.814) | 0.001 | |
Neoadjuvant radiotherapy | 0.482(0.347–0.670) | < 0.001 | |
Adjuvant radiotherapy | 0.858(0.621–1.185) | 0.353 | |
T4N + M0 | < 0.001 | ||
Only surgery | Reference | ||
Surgery + chemotherapy | 0.530(0.411–0.683) | < 0.001 | |
Neoadjuvant radiotherapy | 0.338(0.215–0.532) | < 0.001 | |
Adjuvant radiotherapy | 0.430(0.334–0.554) | < 0.001 |