A balanced score to predict survival of elderly patients newly diagnosed with glioblastoma

Radiation Oncology

Table 2 UVA of the investigated parameters

UVA	3 m OS	6 m OS	9 m OS	12 m OS	P-value	n	mOS
Age					< 0.001
65–69.9	88%	67%	45%	43%		50	7.8
70–74.9	73%	56%	44%	32%		42	6.6
75–79.9	71%	47%	27%	13%		49	5.5
> 80 years	52%	22%	10%	2%		40	3.2
Gender					0.806
Female	72%	49%	35%	21%		75	6.0
Male	73%	46%	29%	23%		86	5.4
MGMT					0.035
unknown or non-methylated	69%	42%	28%	20%		143	5.0
methylated	83%	72%	48%	34%		38	8.7
KPS					< 0.001
10–40%	29%	0%	0%	0%		7	2.4
50–60%	60%	25%	15%	12%		40	3.4
70–80%	76%	54%	37%	25%		68	6.4
90–100%	80%	65%	43%	32%		46	8.1
EOR					0.004
Biopsy	57%	30%	13%	6%		30	3.1
STR	74%	50%	32%	22%		89	5.9
GTR	76%	55%	39%	31%		59	6.4
Seizures					0.264
no seizures	71%	45%	29%	21%		141	5.6
generalized	68%	47%	32%	16%		22	6.2
focal	82%	73%	54%	45%		12	13.5
Motor deficits before surgery					0.073
no motor deficit	72%	55%	36%	27%		105	6.4
any motor deficit	74%	37%	25%	17%		76	4.9
Motor deficits after surgery					0.001
no motor deficit	82%	65%	45%	35%		89	7.8
any motor deficit	63%	31%	17%	11%		92	4.1
Aphasia before surgery					0.132
no aphasia	72%	52%	35%	27%		129	6.2
aphasia	74%	38%	23%	13%		52	5.0
Aphasia after surgery					0.044
no aphasia	85%	62%	42%	31%		107	7.3
aphasia	81%	44%	29%	14%		29	5.7

Abbreviations: UVA Univariate analysis, KPS Karnofsky Performance Scale, MGMT O6-Methylguanine DNA-methyl transferase, EOR Extent of resection, STR Subtotal resection, GTR Gross total resection

ISSN: 1748-717X