Single-center versus multi-center data sets for molecular prognostic modeling: a simulation study

Radiation Oncology

Table 2 Quality of MSPE-estimation by SC and MC validation data sets

Signature	approx. MSPE	SEM	Validation	estim. MSPE	SEM	squared error	SEM
SC	5.74	0.14	SC	5.49	0.17	15.68	2.04
			MC	5.49	0.12	2.73	0.31
MC	0.87	<0.01	SC	0.87	0.01	0.06	<0.01
			MC	0.88	0.01	0.02	<0.01

The average true MSPE value of a signature discovered in SC or MC data is approximated in 1000 iterations by 10⁵ sample data sets with different random batch patterns on each sample. The approximated MSPE-value is reported with its standard error of the mean as well as the MSPE estimated in the validation data and its standard error. The average squared error of this estimator ((MSPE_estim−MSPE_approx)²) was calculated from 1000 discovery data sets with 100 independent validation data sets each

ISSN: 1748-717X