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Table 4 Literature review of retrospective studies evaluating multi-fraction stereotactic radiosurgery

From: A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis

  # patients; # lesions Median f/u (mos) Tumor size (cm3) Median dose (BED10) 1-year LC Symptomatic RN Prior WBRT Prior resection
Median BED > 50
 Minniti et al. [24] 135;171 11.4 10.1 9Gy × 3 (51.3) (≥2 cm)
12Gy ×  3 (79.2) (< 2 cm)
88% 6% 0 0
 Aoyama et al. [38] 87; 159 6.3 3.3 8.75 ×  4a (65.6) 81% 2.7% 0 0
 Ernst-Stecken et al. [16] 51; 72 7 13 7Gy × 5 (59.5) (n = 22)
6Gy ×  5 (w/ WBRT) (48) (n = 29)
76% NS NS NS
 Fahrig et al. [17] 150; 228 28 6.1 5Gy × 7 (52.5) (n = 63)
7Gy × 5 (59.5Gy) (n = 51)
4Gy ×10 (56) (n = 36)
96%
87%
85%
NS 0 13%
 Ogura et al. [23] 39; 46 9.5 3.7 7Gy × 5 (59.5) 87% 2.5% 71% 0
 Manning et al. [20] 32; 57 9.2 2.2 9Gy × 3a (51.3) 91% 6% NS 19%
 Jeong et al. [18] 37; 38 10 17.6 35Gy in 3/5 fxs (59–76) 87% 16% 0 0
 Inoue et al. [39] 78; 85 8 12.6 6.2Gy × 5 (50.2) 93% 2% 13% 0
 Navarria et al. [22] 102; 102 14 16.3 9Gy ×3 (51.3) (n = 51)
8Gy × 4 (57.6) (n = 51)
96% 6% 0 0
 Chon et al. [37] 38 lesions 14 NS 7Gy x5a 92% 5% 0 0
 Jeon et al. 2019 [46] 45; 52 10.5 14.2 8Gy × 3 (43) (n = 19)
9Gy × 3 (51.3) (n = 19)
10Gy ×  3(60) (n = 14)
77%/100%b 17.8% 0 0
Median BED <50Gy
 Marcrom et al. [40] 72; 182 5 2 5Gy × 5 (37.5) (n = 48 lesions)
6Gy ×  5 (48) (n = 134 lesions)
75%
91%
6% 7% 0
 Narayana et al. [41] 20 patients NS NS 6Gy × 5 (45) 70% NS 0% 0
 Kwon et al. [19] 27; 52 6.6 0.5 5Gy x 5a (37.5Gy) 68% 5.8% 86% 0
  1. LC local control, RN radiation necrosis, WBRT whole-brain radiation therapy, NS not specified
  2. aMedian dose regimen
  3. bDaily treatment/every other day treatment