Table 4 Literature review of retrospective studies evaluating multi-fraction stereotactic radiosurgery
| Â | # patients; # lesions | Median f/u (mos) | Tumor size (cm3) | Median dose (BED10) | 1-year LC | Symptomatic RN | Prior WBRT | Prior resection |
|---|---|---|---|---|---|---|---|---|
Median BED > 50 | ||||||||
 Minniti et al. [24] | 135;171 | 11.4 | 10.1 | 9Gy × 3 (51.3) (≥2 cm) 12Gy ×  3 (79.2) (< 2 cm) | 88% | 6% | 0 | 0 |
 Aoyama et al. [38] | 87; 159 | 6.3 | 3.3 | 8.75 ×  4a (65.6) | 81% | 2.7% | 0 | 0 |
 Ernst-Stecken et al. [16] | 51; 72 | 7 | 13 | 7Gy × 5 (59.5) (n = 22) 6Gy ×  5 (w/ WBRT) (48) (n = 29) | 76% | NS | NS | NS |
 Fahrig et al. [17] | 150; 228 | 28 | 6.1 | 5Gy × 7 (52.5) (n = 63) 7Gy × 5 (59.5Gy) (n = 51) 4Gy ×10 (56) (n = 36) | 96% 87% 85% | NS | 0 | 13% |
 Ogura et al. [23] | 39; 46 | 9.5 | 3.7 | 7Gy × 5 (59.5) | 87% | 2.5% | 71% | 0 |
 Manning et al. [20] | 32; 57 | 9.2 | 2.2 | 9Gy × 3a (51.3) | 91% | 6% | NS | 19% |
 Jeong et al. [18] | 37; 38 | 10 | 17.6 | 35Gy in 3/5 fxs (59–76) | 87% | 16% | 0 | 0 |
 Inoue et al. [39] | 78; 85 | 8 | 12.6 | 6.2Gy × 5 (50.2) | 93% | 2% | 13% | 0 |
 Navarria et al. [22] | 102; 102 | 14 | 16.3 | 9Gy ×3 (51.3) (n = 51) 8Gy × 4 (57.6) (n = 51) | 96% | 6% | 0 | 0 |
 Chon et al. [37] | 38 lesions | 14 | NS | 7Gy x5a | 92% | 5% | 0 | 0 |
 Jeon et al. 2019 [46] | 45; 52 | 10.5 | 14.2 | 8Gy × 3 (43) (n = 19) 9Gy × 3 (51.3) (n = 19) 10Gy ×  3(60) (n = 14) | 77%/100%b | 17.8% | 0 | 0 |
Median BED <50Gy | ||||||||
 Marcrom et al. [40] | 72; 182 | 5 | 2 | 5Gy × 5 (37.5) (n = 48 lesions) 6Gy ×  5 (48) (n = 134 lesions) | 75% 91% | 6% | 7% | 0 |
 Narayana et al. [41] | 20 patients | NS | NS | 6Gy × 5 (45) | 70% | NS | 0% | 0 |
 Kwon et al. [19] | 27; 52 | 6.6 | 0.5 | 5Gy x 5a (37.5Gy) | 68% | 5.8% | 86% | 0 |