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Table 3 Univariate and multivariate analysis for radiation necrosis

From: A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis

  Unadjusted HR (95% CI) Unadjusted p-value Adjusted HR (95% CI) Adjusted p-value
Covariate
 Univariate
  Location of metastasis 0.94 (0.35, 2.56) 0.91 1.01 (0.41, 2.47) 0.98
  Tumor size ≤2 cm 0.26 (0.11, 0.59) 0.001 0.25 (0.12, 0.54) < 0.001
  Histologya 1.70 (0.40, 7.25) 0.47 1.77 (0.45, 6.95) 0.41
  Surgical resection 1.92 (0.57, 6.46) 0.29 1.71 (0.55, 5.35) 0.35
  SF vs HF-SRS 1.07 (0.44, 2.61) 0.88 0.81 (0.36, 1.83) 0.61
  Concurrent systemic therapy 0.55 (0.20, 1.48) 0.24 0.49 (0.19, 1.26) 0.14
  Prior WBRT 1.72 (0.76, 3.90) 0.20 1.41 (0.66, 3.02) 0.37
 Multivariate
  SF- vs HF-SRS 0.90 (0.28, 2.87) 0.86 0.96 (0.30, 3.03) 0.94
  Tumor size ≤2 cm 0.20 (0.07, 0.57) 0.003 0.21 (0.07, 0.58) 0.003
  Prior WBRT 1.35 (0.45, 4.03) 0.59 1.13 (0.35, 3.59) 0.84
  1. aHistology was analyzed on UVA based on the 5 subgroups listed in Table 1 and was not statistically significant. To simplify, it is reported as a binary (squamous vs non-squamous) variable in this table