Table 3 Univariate and multivariate analysis for radiation necrosis

  Location of metastasis

0.94 (0.35, 2.56)

0.91

1.01 (0.41, 2.47)

0.98

  Tumor size ≤2 cm

0.26 (0.11, 0.59)

0.001

0.25 (0.12, 0.54)

< 0.001

  Histology^a

1.70 (0.40, 7.25)

0.47

1.77 (0.45, 6.95)

0.41

  Surgical resection

1.92 (0.57, 6.46)

0.29

1.71 (0.55, 5.35)

0.35

  SF vs HF-SRS

1.07 (0.44, 2.61)

0.88

0.81 (0.36, 1.83)

0.61

  Concurrent systemic therapy

0.55 (0.20, 1.48)

0.24

0.49 (0.19, 1.26)

0.14

  Prior WBRT

1.72 (0.76, 3.90)

0.20

1.41 (0.66, 3.02)

0.37

  SF- vs HF-SRS

0.90 (0.28, 2.87)

0.86

0.96 (0.30, 3.03)

0.94

  Tumor size ≤2 cm

0.20 (0.07, 0.57)

0.003

0.21 (0.07, 0.58)

0.003

  Prior WBRT

1.35 (0.45, 4.03)

0.59

1.13 (0.35, 3.59)

0.84