Skip to main content

Table 2 Univariate and multivariate analysis for local failure

From: A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis

  Unadjusted HR (95% CI) Unadjusted p-value Adjusted HR (95% CI) Adjusted p-value
Covariate
 Univariate
  Location of metastasis 1.07 (0.46, 2.50) 0.88 1.01 (0.47, 2.19) 0.98
  Tumor size ≤2 cm 0.40 (0.19, 0.88) 0.02 0.44 (0.22, 0.88) 0.02
  Histologya 1.26 (0.30, 5.30) 0.75 1.21 (0.31, 4.76) 0.78
  Surgical resection 1.44 (0.44, 4.75) 0.54 1.42 (0.49, 4.12) 0.52
  SF vs HF-SRS 2.10 (1.03, 4.33) 0.04 1.73 (0.90, 3.33) 0.10
  Concurrent systemic therapy 0.79 (0.35, 1.78) 0.57 0.67 (0.31, 1.44) 0.30
  Prior WBRT 1.97 (0.96, 4.04) 0.07 1.58 (0.82, 3.03) 0.17
 Multivariate
  SF- vs HF-SRS 1.99 (0.84, 4.76) 0.12 1.65 (0.70, 3.87) 0.25
  Tumor size ≤2 cm 0.49 (0.20, 1.17) 0.11 0.53 (0.23, 1.24) 0.14
  Prior WBRT 2.10 (0.92, 4.81) 0.08 1.83 (0.77, 4.38) 0.17
  1. aHistology was analyzed on UVA based on the 5 subgroups listed in Table 1 and was not statistically significant. To simplify, it is reported as a binary (squamous vs non-squamous) variable in this table