Combined radiotherapy and concurrent tumor treating fields (TTFields) for glioblastoma: Dosimetric consequences on non-coplanar IMRT as initial results from a phase I trial

Table 2 Acuros XB dose calculation: accumulated dose-volume characteristics for the CTV and organs at risk. Each row indicates data from a separate patient

CTV D95 without / with electrodes	CTV EUD without / with electrodes	Accumulated min surface dose to the hottest 1 cm² in shells up to 2, 4, 6, 8, 10 mm without electrodes	Accumulated min surface dose to the hottest 1 cm² in shells up to 2, 4, 6, 8, 10 mm with electrodes	D2 Brain - PTV without / with electrodes
100.9 / 99.7	102.4 / 101.3	69.5 / 80.0 / 88.7 / 94.5 / 102.5	77.8 / 82.0 / 87.7 / 96.3 / 100.5	83.1 / 82.5
97.9 / 99.8	100.8 / 99.9	87.5 / 99.4 /100.9 /100.5 /103.4	92.3 / 100.5 /100.5 /101.3 /103.9	88.0 / 87.0
94.4 / 93.7	97.2 / 96.6	92.1 / 97.6 / 99.0 / 98.8 / 101.0	99.9 / 99.6 / 98.9 / 98.1 / 99.3	93.4 / 92.7
96.8 / 96.3	101.0 / 100.4	97.5 /105.4 /102.5 /102.8 /106.8	101.9 /108.6 /102.9/ 102.3/ 105.6	93.8 / 97.8
98.2 / 97.5	100.1 / 99.4	82.2 / 100.5/ 102.7/ 103.6/ 104.8	88.0 / 100.2/ 101.7/ 102.6/ 103.7	74.9 / 74.9
98.4 / 97.8	101.0 / 100.3	93.8 / 103.8/ 104.6/ 105.0/ 106.3	102.3/ 104.0/ 104.5/ 104.9 /106.0	98.7 / 98.0
96.6 / 96.4	99.6 / 99.5	83.8 / 97.3 / 98.6 / 99.7 / 99.9	90.3 / 100.3/ 99.5 / 99.7 / 99.5	86.2 / 86.0

Note: doses are given as relative doses normalized to the prescribed dose; five adjacent scalp + calvaria layers were defined as tissue slices of 2 mm thickness below the surface of the scalp in a depth of 0–2 mm, 2–4 mm, 4–6 mm, 6–8 mm and 8–10 mm; D95: minimum dose in 95% most exposed voxel of the structure; D2: minimum dose in the 2% most exposed voxels of the structure

ISSN: 1748-717X