Table 5 Literature review of hypofractionated stereotactic studies
Publication date | Nb pts/BM | Median Volume (cc) or size (mm) | Regimen | Isodose (%) | WBRT (%) | LC at 12 m (%) | Median OS at 12 m (%) | RN (%) | Prognostic factors |
|---|---|---|---|---|---|---|---|---|---|
Matsuyama et al. 2005–2009 | 299/573 | 8.6 mm (2.8–47.4) | Variable regimen | NC | 10 | 94 | 57,8 | 2 | Size |
LIiang-hua et al. 2001–2011 | 171/354 | 14.3 cc (0.16–86) | 4 × 8 Gy | 80–90 | 68 | 68 | 51 | 6 | WBRT for OS |
Martens et al. 2006–2010 | 75/108 | 1 cc (0.1–29.2) | 6Gyx5 6-7x5gy 7-10 × 4 Gy | NC | 52 | 52 | 35 | 1 | Volume |
Giubilei et al. 2001–2006 | 30/44 | 4.8 cc (0.4–24.3) | 3 × 6 Gy 4 × 8 Gy | Isocenter | 100 | 86 | 36 | 0 | NC |
Marchetti et al. 2001–2005 | 65/81 | 8 cc (0.3–48.2) | 3 × 8 Gy | 80 | 44 | 58 | 25 | 1 | NC |
Fahrig et al. 2000–2005 | 150/228 | 30 mm | 5 × 6-7Gy 10x4Gy 7 × 5 Gy | NC | 34 | NC | 66 | NC | Dose volume |
Jiang et al. 2003–2009 | 40/NC | 30 mm (3.1–5.5) 17,5 cc (6–64.6) | 4 × 10 gy | 90 | 25 | 94.2 | 55.3 | 2.5 | Histology KPS |
Scorsettiet al. 2004–2007 | 78/113 | 3.3 cc (0.1–28) | 6x4Gy 7x5Gy 1 × 20 Gy | 80 | 10 | 69 | NC | NC | RPA |
Nagai et al. 2009–2013 | 54/128 | 1.9 cc (0.1–18) | 4 × 7 Gy | 80 | NC | 91 | 52 | 0 | NC |
Fokas et al. 2012 | 214/214 | 30 mm | 7 × 5 Gy 4x10Gy | Isocenter | 0 | 90 | 31 | NC | RPA |
Ernst et al. 2003–2005 | 51/72 | 3 cc | 5 × 7 Gy 5 × 6 Gy | NC | NC | NC | NC | NC | V4 < 20 cc |
Inoue et al. 2010–2014 | 88/92 | 10 -74 cc | 3 × 9 Gy 3x10Gy | 57 | 0 | 90 | NC | 0 | V14 RN |