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Table 4 Univariate and multivariate analyses of factors influencing OS of lung cancer patients with brain metastases

From: Whole brain radiation therapy plus focal boost may be a suitable strategy for brain metastases in SCLC patients: a multi-center study

FactorsMedian
OS, months
UnivariateMultivariate
HR
(95% CI)
P ValueHR
(95% CI)
P Value
Age, years< 6015.9 0.019  
≥6010.81.42 (1.06–1.91)   
SexMale10.0 0.016 0.002
Female17.20.67 (0.48–0.93) 0.58 (0.41–0.81) 
KPS≤8011.0 0.059  
> 8014.80.75 (0.56–1.01)   
Number of BMs1–319.5 < 0.001 < 0.001
> 38.92.00 (1.48–2.71) 1.88 (1.36–2.59) 
Maximum size of< 2011.7 0.173  
BM, mm≥2012.91.22 (0.91–1.63)   
Symptoms of BMYes12.3 0.198  
None12.90.83 (0.62–1.11)   
Extracranial metastasesYes7.5 0.003 0.011
None18.30.68 (0.43–1.06) 0.63 (0.40–0.99) 
Unknown15.00.57 (0.42–0.79) 0.61 (0.43–0.85) 
Systematic TxCTx14.9 < 0.001 < 0.001
No-CTx6.01.83 (1.35–2.49) 2.08 (1.53–2.84) 
RadiotherapyWBRT+boost17.9 0.002  
WBRT8.71.82 (1.30–2.55)   
SRS14.51.23 (0.75–2.02)   
  1. Abbreviations: OS overall survival, HR hazard ratio, CI confidence interval, KPS Karnofsky Performance Status, BM brain metastasis, CTx chemotherapy, No-CTx no chemotherapy, WBRT whole brain radiation therapy, SRS stereotactic radiosurgery, WBRT+boost whole brain radiotherapy plus focal radiation boost