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Table 2 Association between patient-, tumor-, and therapy-related characteristics and Grade ≥ 2 radiation pneumonitis (N = 169)

From: Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy

Parameter

Univariable Analysis

Multivariable Analysis

HR

95% CI

P

HR

95% CI

P

Sex

 Female

1

  

1

  

 Male

1.216

0.773–1.915

0.398

1.379

0.758–2.511

0.292

Age, years

  < 58

1

  

1

  

  ≥ 58

1.413

0.951–2.098

0.087

1.541

0.997–2.383

0.052

Histology

 SCLC

1

  

1

  

 NSCLC

1.195

0.791–1.804

0.398

1.251

0.727–2.153

0.418

Stage

 I-II

1

  

1

  

 III-IV

1.100

0.601–2.013

0.758

1.132

0.593–2.163

0.707

KPS

 80–100

1

  

1

  

  < 80

1.341

0.877–2.052

0.176

1.566

0.993–2.470

0.054

Smoking

 Smoker

1

  

1

  

 Nonsmoker

0.926

0.619–1.386

0.708

0.964

0.337–2.192

0.435

Surgery

 Yes

1

  

1

  

 No

1.014

0.684–1.504

0.945

0.690

0.390–1.223

0.204

Chemotherapy

 Yes

1

1

 

1

  

 No

0.500

0.203–1.233

0.132

0.473

0.189–1.187

0.111

CRT

 Yes

1

  

1

  

 No

0.843

0.529–1.344

0.472

0.956

0.575–1.588

0.861

IMRT

 Yes

1

  

1

  

 No

1.077

0.726–1.598

0.712

1.098

0.710–1.699

0.675

Radiation dose, cGy

 <5600

1

  

1

  

  ≥ 5600

1.083

0.729–1.610

0.692

1.139

0.633–2.535

0.737

MLD, cGy

  < 1500

1

  

1

  

  ≥ 1500

1.510

1.093–2.235

0.045

1.888

1.186–3.004

0.007

V20

  < 24%

1

  

1

  

  ≥ 24%

1.730

1.138–2.631

0.010

2.126

1.338–3.378

0.001

COPD

 Yes

1

  

1

  

 No

0.639

0.246–1.661

0.358

0.780

0.339–1.998

0.472

  1. Note: Multivariable analyses were adjusted for all of the factors in this table, statistically significant p values for multivariable analysis were shown in boldface.
  2. *Either MLD or V20 was used in the multivariable analyses, but not both
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Radiation Oncology

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