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Table 2 Univariate and multivariate cox regression analysis on local, locoregional, distant and overall failure rates and overall (OS), disease-specific (DSS) and disease-free (DFS) survival rates; HPV positive oropharyngeal carcinoma (HPVOPC) and lymph node status (> = N2c) were tested as categorial variables. Gross tumor volume (GTV in cubic centimetres) and Hemoglobine (in g/dl) were tested as continuous variables

From: Definitive chemoradiotherapy in patients with squamous cell cancers of the head and neck - results from an unselected cohort of the clinical cooperation group “Personalized Radiotherapy in Head and Neck Cancer”

 

Univariate

Multivariate

HR

95% CI

p-value

HR

95% CI

p-value

Local failure (LF)

 HPVOPC

0.22

0.05–0.90

0.035*

0.21

0.05–0.89

0.035*

 GTV (continuous per 10 cc)

1.04

1.02–1.07

0.0004*

1.04

1.02–1.07

0.0004*

 > =N2c

1.36

0.72–2.55

0.342

–

–

–

 Hemoglobine (continuous per g/dl)

0.87

0.74–1.02

0.082

–

–

–

Locoregional failure (LRF)

 HPVOPC

0.18

0.44–0.76

0.019*

0.18

0.04–0.73

0.017*

 GTVp (continuous per 10 cc)

1.04

1.02–1.07

0.001*

1.04

1.02–1.07

0.001*

 > =N2c

1.52

0.86–2.17

0.150

–

–

–

 Hemoglobine (continuous per g/dl)

0.86

0.74–1.001

0.052

–

–

–

Distant failure (DF)

 HPVOPC

1.15

0.43–3.07

0.787

–

–

–

 GTV (continuous per 10 cc)

1.01

0.97–1.05

0.590

–

–

–

 > =N2c

2.85

1.42–5.74

0.003*

–

–

–

 Hemoglobine (continuous per g/dl)

0.95

0.79–1.14

0.549

–

–

–

Any failure (AF)

 HPVOPC

0.39

0.16–0.99

0.047*

0.37

0.15–0.94

0.037*

 GTV (continuous per 10 cc)

1.04

1.01–1.06

0.001*

1.03

1.01–1.05

0.018*

 > =N2c

1.95

1.20–3.18

0.007*

1.90

1.07–3.37

0.029*

 Hemoglobine (continuous per g/dl)

0.89

0.77–1.02

0.090

–

–

–

Overall survival (OAS)

 HPVOPC

0.30

0.15–0.63

0.001*

0.27

0.12–0.59

0.001*

 GTV (continuous per 10 cc)

1.03

1.02–1.05

0.0001*

1.03

1.01–1.04

0.010*

 > =N2c

1.82

1.25–2.65

0.002*

1.48

0.96–2.27

0.073

 Hemoglobine (continuous per g/dl)

0.88

0.80–0.97

0.009*

0.95

0.85–1.06

0.335

Disease specific survival (DSS)

 HPVOPC

0.09

0.01–0.63

0.016*

0.09

0.01–0.69

0.020*

 GTV (continuous per 10 cc)

1.04

1.02–1.07

0.0003*

1.03

1.004–1.06

0.027*

 > =N2c

2.57

1.47–4.49

0.001*

2.23

1.15–4.34

0.018*

 Hemoglobine (continuous per g/dl)

0.84

0.73–0.98

0.023*

0.91

0.76–1.08

0.268

Disease free survival (DFS)

 HPVOPC

0.38

0.20–0.71

0.003*

0.37

0.19–0.71

0.003*

 GTV (continuous per 10 cc)

1.03

1.02–1.05

0.00006*

1.03

1.01–1.05

0.004*

 > =N2c

1.65

1.16–2.34

0.006*

1.49

0.99–2.24

0.056

 Hemoglobine (continuous per g/dl)

0.90

0.82–0.97

0.024*

0.96

0.87–1.07

0.438

  1. *P-values < 0.05 were marked with asterisk
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Radiation Oncology

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