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Table 2 Definitions, calculations and interpretations of introduced terms

From: Is in vivo and ex vivo irradiation equally reliable for individual Radiosensitivity testing by three colour fluorescence in situ hybridization?

deposited energyEdepCalculation: Is the volume inside the isodose levels multiplied by the density ρ and the assigned dose and summed up for the isodose levels 20, 30, 40, 60, 80, 90 and 95%.
Interpretation: An estimation of total absorbed radiation energy.
chromosomal aberration correction factorcfCalculation: Is derived from a linear quadratic fit for the induction of chromosomal aberrations in dependence of dose.
Interpretation: chromosomal aberrations are non-linear induced in dependence of dose. In low dose areas relative lower amounts of aberrations are induced compared to higher dose regions.
effective deposited energy\( {E}_{dep}^{eff} \)Calculation: Is calculated according to the deposited energy while including the chromosomal aberration correction factor (cf) for each isodose level.
Interpretation: The dose dependence of the induction of chromosomal aberrations is included.
estimated average doseEADCalculation: Is the deposited/absorbed radiation energy of an individual divided by the mass of this individual.
Interpretation: It should reflect the exposed average dose of the blood and respectively the blood lymphocytes.
normalized breaks per metaphaseB/MnormCalculation: The B/M of an individual is multiplied by the average EAD of the whole cohort divided by the EAD of the individual.
Interpretation: The B/M values of all individuals are normalized to the same dose.
radiosensitivity factor--Calculation: The breaks per metaphase of an individual divided by the average B/M of all individuals for the 2Gy ex vivo irradiation.
Interpretation: A factor for each individual giving the deviation from the average radiosensitivity expressed as chromosomal aberrations.