Fig. 1

Radiotherapy induced immune modulation protocol schematic: this figure describes the three phases of the timing of SBRT-PATHY protocol as: (a) the monitoring, collection and analysis of serial data to establish the presence of immune cycle and its periodicity (blue dots and line), (b) projection forward to the putative “most favorable time-position in a cycle” (red circles) or “less favorable time-position“(green circle) to initiate radiotherapy, (c) evaluate at follow-up via scans to provide the evidence for patient responses stratification determined by timing of the treatment