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Table 5 Dose differences (averaged over the 20 validation patients) for some structures and target parameters, using different RapidPlan models. Error is reported as standard error of the mean. In parenthesis the p values. Targets and non-targe tissue have no DVH estimation from the RP process

From: RapidPlan knowledge based planning: iterative learning process and model ability to steer planning strategies

 

CL-2 – CL-1

TP-2 – TP-1

CL-1 – TP-1

BrainStem, D1% (Gy)

3.8% ± 1.8% (0.054)

−8.8% ± 1.7% (< 0.001)

−29.6% ± 4.7% (< 0.001)

SpinalCord, D1% (Gy)

2.7% ± 1.6% (0.119)

−5.5% ± 1.2% (< 0.001)

−19.0% ± 2.2% (< 0.001)

Parotids, Mean (Gy)

−0.5% ± 0.4% (0.159)

−0.9% ± 0.4% (0.029)

−1.8% ± 0.4% (< 0.001)

OralCavity, Mean (Gy)

−1.0% ± 0.3% (0.007)

0.1% ± 0.3% (0.713)

0.8% ± 0.2% (0.008)

Larynx, Mean (Gy)

− 5.1% ± 0.8 (< 0.001)

−11.5% ± 1.6% (< 0.001)

− 14.1% ± 1.8 (< 0.001)

Thyroid, Mean (Gy)

−0.5% ± 0.4% (0.277)

1.9% ± 0.4% (< 0.001)

1.1% ± 0.5% (0.042)

PTV_boost, D2% (Gy)

0.0% ± 0.1% (0.881)

0.0% ± 0.1% (0.209)

0.0% ± 0.1% (0.431)

PTV_boost, D98% (Gy)

−0.1% ± 0.1% (0.130)

−0.1% ± 0.1% (0.244)

0.0% ± 0.1% (0.551)

PTV_boost, St.Dev. (Gy)

1.1 ± 0.8% (0.208)

0.8% ± 0.7% (0.269)

−0.4% ± 1.0% (0.661)

PTV_elective, D5% (Gy)

0.1% ± 0.1% (0.093)

0.0% ± 0.1% (0.396)

0.1% ± 0.1% (0.077)

PTV_elective, D95% (Gy)

−0.1% ± 0.1% (0.092)

−0.1% ± 0.1% (0.307)

−0.7% ± 0.1% (< 0.001)

PTV_elective, St.Dev. (Gy)

1.8% ± 0.7% (0.021)

0.9% ± 0.7% (0.198)

6.6% ± 0.7% (< 0.001)

Non-target tissue, Mean (Gy)

0.4% ± 0.2% (0.094)

−0.1% ± 0.1% (0.647)

−18.6% ± 6.9% (0.017)