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Table 5 Dose differences (averaged over the 20 validation patients) for some structures and target parameters, using different RapidPlan models. Error is reported as standard error of the mean. In parenthesis the p values. Targets and non-targe tissue have no DVH estimation from the RP process

From: RapidPlan knowledge based planning: iterative learning process and model ability to steer planning strategies

  CL-2 – CL-1 TP-2 – TP-1 CL-1 – TP-1
BrainStem, D1% (Gy) 3.8% ± 1.8% (0.054) −8.8% ± 1.7% (< 0.001) −29.6% ± 4.7% (< 0.001)
SpinalCord, D1% (Gy) 2.7% ± 1.6% (0.119) −5.5% ± 1.2% (< 0.001) −19.0% ± 2.2% (< 0.001)
Parotids, Mean (Gy) −0.5% ± 0.4% (0.159) −0.9% ± 0.4% (0.029) −1.8% ± 0.4% (< 0.001)
OralCavity, Mean (Gy) −1.0% ± 0.3% (0.007) 0.1% ± 0.3% (0.713) 0.8% ± 0.2% (0.008)
Larynx, Mean (Gy) − 5.1% ± 0.8 (< 0.001) −11.5% ± 1.6% (< 0.001) − 14.1% ± 1.8 (< 0.001)
Thyroid, Mean (Gy) −0.5% ± 0.4% (0.277) 1.9% ± 0.4% (< 0.001) 1.1% ± 0.5% (0.042)
PTV_boost, D2% (Gy) 0.0% ± 0.1% (0.881) 0.0% ± 0.1% (0.209) 0.0% ± 0.1% (0.431)
PTV_boost, D98% (Gy) −0.1% ± 0.1% (0.130) −0.1% ± 0.1% (0.244) 0.0% ± 0.1% (0.551)
PTV_boost, St.Dev. (Gy) 1.1 ± 0.8% (0.208) 0.8% ± 0.7% (0.269) −0.4% ± 1.0% (0.661)
PTV_elective, D5% (Gy) 0.1% ± 0.1% (0.093) 0.0% ± 0.1% (0.396) 0.1% ± 0.1% (0.077)
PTV_elective, D95% (Gy) −0.1% ± 0.1% (0.092) −0.1% ± 0.1% (0.307) −0.7% ± 0.1% (< 0.001)
PTV_elective, St.Dev. (Gy) 1.8% ± 0.7% (0.021) 0.9% ± 0.7% (0.198) 6.6% ± 0.7% (< 0.001)
Non-target tissue, Mean (Gy) 0.4% ± 0.2% (0.094) −0.1% ± 0.1% (0.647) −18.6% ± 6.9% (0.017)