Table 1 Overview of the width of the esophageal lumen (in case of no ARIED) and hyperintense radiation-induced damage regions in MRI images. The numbers represent the largest width of the radiation-induced signal enhancement. Moreover, the table summarized the MRI and histopathology analysis of the proximal esophagus graded in no ARIED, mild ARIED, and severe ARIED. “—” indicates no ARIED and “NA” indicates not available
Width of enhacement around the esophagus (mm) | ||||||
|---|---|---|---|---|---|---|
Mouse | Group | MRI | Absolute difference (before and post-irradiation) | MRI | Histopathology | |
Before Irradiation | Post-irradiation | Proximal | Proximal | |||
1 | 2 days post-irradiation | 0.19 | 0.05 | 0.14 | – | Mild |
2 | 2 days post-irradiation | 0.20 | 0.15 | 0.05 | – | – |
3 | 2 days post-irradiation | 0.17 | 0.15 | 0.02 | – | Mild |
4 | 2 days post-irradiation | 0.14 | 0.15 | 0.01 | – | Mild |
5 | 2 days post-irradiation | 0.23 | 0.19 | 0.04 | – | Mild |
6 | 2 days post-irradiation | 0.47 | 0.78 | 0.31 | Mild | NA |
7 | 2 days post-irradiation | 0.40 | 0.85 | 0.45 | – | Mild |
8 | 2 days post-irradiation | 0.37 | 0.19 | 0.18 | – | – |
9 | 2 days post-irradiation | 0.15 | 0.25 | 0.10 | – | Mild |
10 | 3 days post-irradiation | 0.17 | 0.15 | 0.02 | – | Mild |
11 | 3 days post-irradiation | 0.28 | 0.52 | 0.24 | Mild | – |
12 | 3 days post-irradiation | 0.19 | 0.52 | 0.33 | Mild | – |
13 | 3 days post-irradiation | 0.21 | 0.42 | 0.21 | Mild | – |
14 | 3 days post-irradiation | 0.08 | 0.80 | 0.72 | Mild | Mild |
15 | 3 days post-irradiation | 0.24 | 1.05 | 0.81 | Mild | Mild |
16 | 3 days post-irradiation | 0.15 | 0.47 | 0.32 | Mild | – |
17 | 7 days post-irradiation | 0.11 | 1.19 | 1.08 | severe | severe |
18 | 7 days post-irradiation | 0.19 | 2.26 | 2.07 | severe | severe |
19 | 7 days post-irradiation | 0.45 | 1.77 | 1.32 | severe | severe |
20 | 7 days post-irradiation | 0.36 | 1.96 | 1.60 | severe | severe |
21 | 7 days post-irradiation | 0.39 | 2.44 | 2.05 | severe | severe |
22 | 7 days post-irradiation | 0.34 | 1.68 | 1.34 | severe | NA |
23 | 7 days post-irradiation | 0.40 | 1.95 | 1.55 | severe | severe |
24 | 7 days post-irradiation | 0.18 | 1.88 | 1.70 | severe | severe |
25 | MRI-only | 0.25 | 0.15 | 0.10 | – | – |