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Table 3 Network meta-analysis results

From: Elective nodal irradiation versus involved-field irradiation in patients with esophageal cancer receiving neoadjuvant chemoradiotherapy: a network meta-analysis

a. Network meta-analysis results for five outcomes

OS

nCRTS-ENI

     

0.84(0.62–1.1)

nCRTS-IFI

    

0.73(0.55–0.97)

0.87(0.73–1.0)

nCTS

   

0.63(0.48–0.83)

0.75(0.66–0.86)

0.87(0.77–0.97)

S-alone

  

LR

nCRTS-IFI

     

0.74(0.37–1.5)

nCRTS-ENI

    

0.59(0.37–0.94)

0.61(0.30–1.3)

nCTS

   

0.43(0.30–0.60)

0.58(0.31–1.1)

0.79(0.59–1.1)

S-alone

  

DM

nCRTS-IFI

     

1.0(0.54–1.9)

nCRTS-ENI

    

0.92(0.60–1.4)

0.90(0.50–1.6)

nCTS

   

0.79(0.57–1.1)

0.76(0.44–1.3)

0.85(0.64–1.2)

S-alone

  

POM

S-alone

     

0.99(0.68–1.4)

nCTS

    

0.56(0.33–0.92)

0.56(0.30–1.0)

nCRTS-IFI

   

0.56(0.27–1.1)

0.56(0.27–1.2)

1.0(0.41–2.4)

nCRTS-ENI

  

R0 resection

S-alone

     

0.57(0.40–0.80)

nCTS

    

0.16(0.09–0.28)

0.28(0.14–0.53)

nCRTS-IFI

   

0.16(0.07–0.34)

0.29(0.13–0.59)

1.0(0.39–2.6)

nCRTS-ENI

  

b. Network meta-analysis results of OS for four subgroups

ESCC

nCRTS-IFI

     

0.83(0.47–1.5)

nCRTS-ENI

    

0.78(0.63–0.96)

0.80(0.43–1.5)

nCTS

   

0.50(0.38–0.68)

0.61(0.35–1.0)

0.76(0.57–1.0)

S-alone

  

EAC

nCRTS-ENI

     

0.70(0.37–1.3)

nCRTS-IFI

    

0.65(0.38–1.1)

0.93(0.71–1.3)

nCTS

   

0.50(0.28–0.87)

0.72(0.58–0.91)

0.78(0.62–0.93)

S-alone

  

RT with dose of ≥40Gy/<40Gy

nCRTS-ENI ≥ 40Gy

     

0.90(0.59–1.4)

nCRTS-IFI ≥ 40Gy

    

0.89(0.54–1.5)

0.99(0.70–1.4)

nCRTS-ENI < 40Gy

   

0.71(0.48–1.1)

0.79(0.65–0.96)

0.80(0.58–1.1)

nCTS

  

0.68(0.43–1.1)

0.76(0.56–1.0)

0.76(0.51–1.1)

0.96(0.72–1.3)

nCRTS-IFI < 40Gy

 

0.62(0.43–0.92)

0.70(0.59–0.82)

0.70(0.51–0.96)

0.88(0.78–0.99)

0.92(0.71–1.2)

S-alone

RT with technique of 3DRT/2DRT

nCRTS-ENI-3DRT

     

0.74(0.46–1.2)

nCRTS-IFI-2DRT

    

0.68(0.42–1.1)

0.92(0.68–1.2)

nCRTS-IFI-3DRT

   

0.58(0.34–0.99)

0.87(0.57–1.3)

0.94(0.63–1.4)

nCRTS-ENI-2DRT

  

0.61(0.39–0.94)

0.83(0.64–1.1)

0.90(0.72–1.1)

0.96(0.66–1.4)

nCTS

 

0.53(0.34–0.80)

0.72(0.57–0.88)

0.78(0.64–0.94)

0.82(0.58–1.2)

0.86(0.76–0.98)

S-alone

  1. Abbreviations: OS Overall survival, LR Locoregional recurrence, DM Distant metastases, POM Post-operative mortality, nCRTS Neoadjuvant chemoradiotherapy plus surgery, nCTS Neoadjuvant chemotherapy plus surgery, S Surgery, RT Radiotherapy, ENI Elective nodal irradiation, IFI Involved-field irradiation, ESCC Esophagus squamous cell carcinoma, EAC Esophagus adenocarcinoma, 2D Two-dimensional, 3D Three-dimensional
  2. Significant results are in bold