Table 2 Results of direct comparsions

OS

nCRTS-ENI vs S alone

HR 0.70(0.54–0.92)

nCRTS-IFI vs S alone

HR 0.74(0.66–0.83)

nCTS vs S alone

HR 0.86(0.76–0.98)

LR

nCRTS-ENI vs S alone

OR 0.69(0.35–1.35)

nCRTS-IFI vs S alone

OR 0.43(0.33–0.57)

nCTS vs S alone

OR 0.79(0.62–0.99)

DM

nCRTS-ENI vs S alone

OR 0.87(0.35–2.21)

nCRTS-IFI vs S alone

OR 0.79(0.62–1.00)

nCTS vs S alone

OR 0.83(0.68–1.01)

R0 resection

nCRTS-ENI vs S alone

OR 5.75(2.19–15.13)

nCRTS-IFI vs S alone

OR 5.17(1.95–13.67)

nCTS vs S alone

OR 1.71(1.39–2.10)

nCRTS-ENI vs nCT

OR 4.71(1.98–11.24)

POM

nCRTS-ENI vs S alone

OR 1.52(0.66–3.52)

nCRTS-IFI vs S alone

OR 1.79(1.14–2.82)

nCTS vs S alone

OR 1.02(0.75–1.38)