Table 1 Characteristics of included trials
Trial | Time Range | Region | Treatment | Sample size | Median follow-up | Median Age | pStage | Histology | CT | RT | RT |
|---|---|---|---|---|---|---|---|---|---|---|---|
regimen | dose (Gy) | technique | |||||||||
NEOCRTEC5010/2018 [5] | 2007–2014 | China | nCRTS-IFI | 224 | 41 m | 56 | I-IV | SCC | NP | 40 | 3D |
S alone | 227 | 58 | |||||||||
2004–2008 | Netherlands | nCRTS-IFI | 178 | 84 m | 60 | I-III | SCC/AC | PC | 41.4 | 3D | |
S alone | 188 | 60 | |||||||||
Lv/2010 [8] | 1997–2004 | China | nCRTS-IFI | 80 | 45 m | NR | I-III | SCC | PC | 40 | 2D |
S alone | 80 | ||||||||||
FFCD9901/2014 [9] | 2000–2009 | France | nCRTS-IFI | 98 | 94 m | 58.1 | I-III | SCC/AC | FP | 45 | 3D |
S alone | 97 | 57.6 | |||||||||
IG9401/2005 [10] | 1994–2000 | Australia | nCRTS-IFI | 128 | 65 m | 61 | NR | SCC/AC | FP | 35 | 2D |
S alone | 128 | 62 | |||||||||
Urba/2001 [11] | 1985–1987 | America | nCRTS-IFI | 50 | 98 m | 62 | NR | SCC/AC | FP + Vin | 45 | 3D |
S alone | 50 | 64 | |||||||||
Bosset/1997 [12] | 1989–1995 | France | nCRTS-IFI | 143 | 55 m | 56.6 | I-III | SCC | Cis | 37 | 3D |
S alone | 139 | 56.7 | |||||||||
1990–1995 | Ireland | nCRTS-IFI | 58 | 10 m | 65 | I-IV | AC | FP | 40 | 2D | |
S alone | 55 | 65 | |||||||||
Apinop/1994 [15] | 1986–1992 | Thailand | nCRTS-IFI | 35 | NR | 59.6 | NR | SCC | FP | 40 | 2D |
S alone | 34 | 59.8 | |||||||||
Cao/2009 [16] | 1991–2000 | China | nCRTS-IFI | 118 | NR | NR | II-IV | SCC | FP | 40 | 2D |
nCTS | 119 | ||||||||||
S alone | 118 | ||||||||||
Yanagi/2018 [17] | 1997–2001 | Japan | nCRTS-ENI | 20 | 90 m | 61.5 | I-IV | SCC | FP | 40 | NR |
S alone | 21 | 60 | |||||||||
CALGB9781/2008 [18] | 1997–2000 | America | nCRTS-ENI | 30 | 72 m | 59.9 | NR | SCC/AC | FP | 50.4 | 3D |
S alone | 26 | 62.2 | |||||||||
Natsugoe/2006 [19] | 1997–2001 | Japan | nCRTS-ENI | 22 | 24 m | NR | II-IV | SCC | FP | 40 | NR |
S alone | 23 | ||||||||||
Lee/2004 [20] | 1999–2002 | Korea | nCRTS-ENI | 51 | 25 m | 63 | I-IV | SCC | FP | 45.6 | 2D |
S alone | 50 | 63 | |||||||||
Le Prise/1994 [21] | 1988–1991 | France | nCRTS-ENI | 41 | 16 m | 56 | NR | SCC | FP | 20 | 2D |
S alone | 45 | 59 | |||||||||
Nygaard/1992 [22] | 1983–1988 | Norway | nCRTS-ENI | 53 | NR | 60.1 | NR | SCC | Cis + Ble | 35 | 2D |
nCTS | 56 | 62.9 | |||||||||
S alone | 50 | 61.4 | |||||||||
2000–2005 | Germany | nCRTS-ENI | 60 | 126 m | 60.6 | I-IV | AC | PLF | 30 | 3D | |
nCTS | 59 | 56 | |||||||||
Burmeister/2011 [37] | 2000–2006 | Australia | nCRTS-IFI | 39 | 94 m | 60 | I-III | AC | FP | 35 | 3D |
nCTS | 36 | 63 | |||||||||
Boonstra/2011 [38] | 1989–1996 | Netherlands | nCTS | 85 | 15 m | 60 | I-IV | SCC | EP | ||
S alone | 84 | 14 m | 60 | ||||||||
Ychou/2011 [39] | 1995–2003 | Multicenter | nCTS | 84 | NR | NR | NR | AC | FP | ||
S alone | 85 | ||||||||||
1992–1998 | UK | nCTS | 400 | 73 m | 63 | NR | SCC/AC | FP | |||
S alone | 402 | 63 | |||||||||
MAGIC/2006 [42] | 1994–2002 | Multicenter | nCTS | 65 | NR | NR | NR | AC | ECF | ||
S alone | 66 | ||||||||||
1990–1995 | Multicenter | nCTS | 233 | NR | 61 | NR | SCC/AC | FP | |||
S alone | 234 | 62 | |||||||||
Ancona/2001 [45] | 1992–1997 | Italy | nCTS | 47 | NR | 58 | NR | NR | FP | ||
S alone | 47 | 58 | |||||||||
Baba/2000 [46] | 1993–1995 | Japan | nCTS | 21 | NR | 63.6 | I-IV | SCC | PLF | ||
S alone | 21 | 60.1 | |||||||||
Law/1997 [47] | 1989–1995 | China | nCTS | 74 | 17 m | 64 | I-III | SCC | FP | ||
S alone | 73 | 63 | |||||||||
Schlag/1992 [48] | NR | Germany | nCTS | 35 | 8 m | NR | NR | SCC | FP | ||
S alone | 42 | ||||||||||
Maipang/1994 [49] | 1988–1990 | Thailand | nCTS | 24 | NR | 64.2 | NR | SCC | Cis + Ble | ||
S alone | 22 | 64.8 | |||||||||
Roth/1988 [50] | 1982–1986 | America | nCTS | 19 | 30 m | NR | NR | NR | NP + Ble | ||
S alone | 20 |