| Univariate HR (95% CI) | P | Multivariate HR (95% CI) | P |
---|---|---|---|---|
Age (≥60/< 60) | 1.66 (0.78–3.54) | 0.17 |  |  |
Gender (Female/Male) | 0.64 (0.31–1.31) | 0.204 |  |  |
Smoking status (Smoking/Never) | 1.41 (0.65–3.06) | 0.375 |  |  |
KPS (≥80/< 80) | 0.34 (0.15–0.78) | 0.006 | 0.34 (0.15–0.78) | 0.011 |
EGFR mutation (exon 19 deletion/exon 21 L858R) | 0.77 (0.39–1.52) | 0.43 |  |  |
Co-existing BMs (yes/no) | 0.89 (0.34–2.33) | 0.804 |  |  |
Intracranial symptoms (yes/no) | 1.40 (0.61–3.22) | 0.413 |  |  |
LM at the time of NSCLC diagnosis (yes/no) | 0.60 (0.21–1.72) | 0.324 |  |  |
Treatment for LM | ||||
 WBRT (yes/no) | 0.51 (0.25–1.04) | 0.052 |  |  |
 EGFR-TKIs (yes/no) | 0.45 (0.22–0.91) | 0.019 | 0.442 (0.22–0.91) | 0.027 |
 WBRT+EGFR-TKIs/EGFR-TKIs alone | 0.67 (0.27–1.67) | 0.379 |  |  |