Table 1 Baseline characteristics of enrolled patients
Characteristic | Total (n = 51) n (%) | WBRT (n = 26) n (%) | non-WBRT (n = 25) n (%) | P-value |
|---|---|---|---|---|
Age at the time of LM diagnosis (yr.) | ||||
 Median (range) | 56 (32–81) | 55 (32–81) | 56 (37–73) | 0.843 |
 < 60 | 34 (66.7) | 17 (65.4) | 17 (68) |  |
 ≥ 60 | 17 (33.3) | 9 (34.6) | 8 (32) |  |
Gender | ||||
 Male | 17 (33.3) | 8 (30.8) | 9 (36) | 0.692 |
 Female | 34 (66.7) | 18 (69.2) | 16 (64) |  |
Smoking status | ||||
 Non-smoker | 40 (78.4) | 21 (80.8) | 19 (76) | 0.679 |
 Former/current-smoker | 11 (21.6) | 5 (19.2) | 6 (24) |  |
KPS at the time of LM diagnosis | ||||
 ≥ 80 | 39 (76.5) | 21 (80.8) | 18 (72) | 0.46 |
 < 80 | 12 (23.5) | 5 (19.2) | 7 (28) |  |
Pathological classification | ||||
 Adenocarcinoma | 50 (98) | 26 (100) | 24 (96) | 0.49 |
 Squamous cell carcinoma | 1 (2) | 0 (0) | 1 (4) |  |
EGFR mutation status | ||||
 Exon 19 deletion | 20 (39.2) | 5 (19.2) | 15 (60) | 0.004 |
 Exon 21 L858R | 31 (60.8) | 21 (80.8) | 10 (40) |  |
LM present at the initial diagnosis of NSCLC | ||||
 Yes | 9 (17.6) | 6 (23.1) | 3 (12) | 0.465 |
 No | 42 (82.4) | 20 (76.9) | 22 (88) |  |
LM-related Symptoms and signs | ||||
 Asymptomatic | 12 (23.5) | 4 (15.4) | 8 (32) | 0.199 |
 Symptomatic | 39 (76.5) | 22 (84.6) | 17 (68) |  |
The modality of LM diagnosis | ||||
 MRI+ | 11 (21.6) | 6 (23.1) | 5 (20) | 0.789 |
 MRI+/cytology+ | 40 (78.4) | 20 (76.9) | 20 (80) |  |
Co-existing BMs | ||||
 Yes | 44 (86.3) | 24 (92.3) | 20 (80) | 0.248 |
 No | 7 (13.7) | 2 (7.7) | 5 (20) |  |
Extracranial metastases at the time of LM diagnosis | ||||
 Yes | 37 (72.5) | 17 (65.4) | 19 (76) | 0.406 |
 No | 14 (27.5) | 9 (34.6) | 6 (24) |  |