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Table 3 Multivariate regression analysis related to AAT

From: Dose-volume analysis of predictors for acute anal toxicity after radiotherapy in prostate cancer patients

Groups Variables OR (95% CI) P
Training group (N = 248 cases) V10 (%) 1.02 (1.01~1.03) 0.650
V20 (%) 1.03 (1.01~1.04) < 0.001
V30 (%) 1.02 (1.01~1.03) 0.607
V40 (%) 1.02 (1.01~1.04) 0.947
V50 (%) 1.04 (1.01~1.07) 0.847
V60 (%) 1.07 (1.02~1.13) 0.526
Anal canal Dmax (Gy) 1.00 (0.96~1.04) 0.994
Anal canal Dmean (Gy) 1.00 (0.96~1.05) 0.810
Hemorrhoid (cases) 10.94 (5.47~21.89) < 0.001
Validation group (N = 99 cases) V10 (%) 1.04 (1.02~1.06) 0.478
V20 (%) 1.04 (1.02~1.06) < 0.001
V30 (%) 1.02 (1.01~1.04) 0.461
V40 (%) 1.03 (1.01~1.06) 0.676
V50 (%) 1.06 (1.01~1.11) 0.438
V60 (%) 1.12 (1.01~1.24) 0.559
Anal canal Dmean (Gy) 1.06 (1.02~1.11) 0.712
Hemorrhoid (cases) 5.34 (1.85~15.39) < 0.001
  1. Abbreviations: AAT acute anal toxicity; OR odds ratio; CI confidence interval; V10–V60 = percentage of anal canal volume receiving more than 10–60 Gy; Dmax = maximum dose; Dmean = minimum dose