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Table 3 Multivariate regression analysis related to AAT

From: Dose-volume analysis of predictors for acute anal toxicity after radiotherapy in prostate cancer patients

Groups

Variables

OR (95% CI)

P

Training group (N = 248 cases)

V10 (%)

1.02 (1.01~1.03)

0.650

V20 (%)

1.03 (1.01~1.04)

< 0.001

V30 (%)

1.02 (1.01~1.03)

0.607

V40 (%)

1.02 (1.01~1.04)

0.947

V50 (%)

1.04 (1.01~1.07)

0.847

V60 (%)

1.07 (1.02~1.13)

0.526

Anal canal Dmax (Gy)

1.00 (0.96~1.04)

0.994

Anal canal Dmean (Gy)

1.00 (0.96~1.05)

0.810

Hemorrhoid (cases)

10.94 (5.47~21.89)

< 0.001

Validation group (N = 99 cases)

V10 (%)

1.04 (1.02~1.06)

0.478

V20 (%)

1.04 (1.02~1.06)

< 0.001

V30 (%)

1.02 (1.01~1.04)

0.461

V40 (%)

1.03 (1.01~1.06)

0.676

V50 (%)

1.06 (1.01~1.11)

0.438

V60 (%)

1.12 (1.01~1.24)

0.559

Anal canal Dmean (Gy)

1.06 (1.02~1.11)

0.712

Hemorrhoid (cases)

5.34 (1.85~15.39)

< 0.001

  1. Abbreviations: AAT acute anal toxicity; OR odds ratio; CI confidence interval; V10–V60 = percentage of anal canal volume receiving more than 10–60 Gy; Dmax = maximum dose; Dmean = minimum dose