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Table 2 Univariate analysis of DVH parameters related to AAT

From: Dose-volume analysis of predictors for acute anal toxicity after radiotherapy in prostate cancer patients

  Training group (N = 248 cases) Validation group (N = 99 cases)
Variables NAAT (Mean ± SD) AAT (Mean ± SD) P NAAT (Mean ± SD) AAT (Mean ± SD) P
Prescribed Dose (Gy) 67.04 ± 5.02 67.33 ± 5.77 0.672 69.12 ± 4.65 67.35 ± 3.96 0.073
Volume of anal canal (cm3) 9.43 ± 4.02 10.02 ± 3.60 0.232 9.33 ± 3.51 8.00 ± 3.17 0.080
Anal canal Dmax (Gy) 59.51 ± 12.95 63.22 ± 9.65 0.018 54.47 ± 13.83 58.40 ± 11.13 0.169
Anal canal Dmean (Gy) 26.04 ± 12.60 30.25 ± 9.71 0.010 22.51 ± 9.61 29.43 ± 11.52 0.005
V10 (%) 75.61 ± 22.45 84.48 ± 18.89 0.002 67.82 ± 22.35 85.52 ± 18.06 0.001
V20 (%) 58.41 ± 26.62 72.62 ± 25.59 < 0.001 49.71 ± 29.09 74.24 ± 23.84 < 0.001
V30 (%) 37.81 ± 24.32 52.08 ± 26.91 < 0.001 30.65 ± 27.74 49.85 ± 30.98 0.006
V40 (%) 19.31 ± 16.18 27.30 ± 20.44 0.001 13.75 ± 14.98 27.46 ± 25.60 0.009
V50 (%) 8.81 ± 9.09 13.40 ± 13.01 0.002 5.22 ± 6.40 12.83 ± 15.38 0.011
V60 (%) 3.16 ± 4.33 5.34 ± 7.28 0.006 1.66 ± 2.83 3.95 ± 5.59 0.038
V70 (%) 0.08 ± 0.31 0.44 ± 2.13 0.099 0.07 ± 0.24 0.05 ± 0.27 0.785
  1. Abbreviations: DVH dose–volume histograms; AAT acute anal toxicity; NAAT no-acute anal toxicity; Dmax maximum dose; Dmean mean dose; V10–V70 percentage of anal canal volume receiving more than 10–70 Gy