| |
Training group (N = 248 cases)
|
Validation group (N = 99 cases)
|
|---|
|
Variables
|
NAAT (Mean ± SD)
|
AAT (Mean ± SD)
|
P
|
NAAT (Mean ± SD)
|
AAT (Mean ± SD)
|
P
|
|---|
|
Prescribed Dose (Gy)
|
67.04 ± 5.02
|
67.33 ± 5.77
|
0.672
|
69.12 ± 4.65
|
67.35 ± 3.96
|
0.073
|
|
Volume of anal canal (cm3)
|
9.43 ± 4.02
|
10.02 ± 3.60
|
0.232
|
9.33 ± 3.51
|
8.00 ± 3.17
|
0.080
|
|
Anal canal Dmax (Gy)
|
59.51 ± 12.95
|
63.22 ± 9.65
|
0.018
|
54.47 ± 13.83
|
58.40 ± 11.13
|
0.169
|
|
Anal canal Dmean (Gy)
|
26.04 ± 12.60
|
30.25 ± 9.71
|
0.010
|
22.51 ± 9.61
|
29.43 ± 11.52
|
0.005
|
|
V10 (%)
|
75.61 ± 22.45
|
84.48 ± 18.89
|
0.002
|
67.82 ± 22.35
|
85.52 ± 18.06
|
0.001
|
|
V20 (%)
|
58.41 ± 26.62
|
72.62 ± 25.59
|
< 0.001
|
49.71 ± 29.09
|
74.24 ± 23.84
|
< 0.001
|
|
V30 (%)
|
37.81 ± 24.32
|
52.08 ± 26.91
|
< 0.001
|
30.65 ± 27.74
|
49.85 ± 30.98
|
0.006
|
|
V40 (%)
|
19.31 ± 16.18
|
27.30 ± 20.44
|
0.001
|
13.75 ± 14.98
|
27.46 ± 25.60
|
0.009
|
|
V50 (%)
|
8.81 ± 9.09
|
13.40 ± 13.01
|
0.002
|
5.22 ± 6.40
|
12.83 ± 15.38
|
0.011
|
|
V60 (%)
|
3.16 ± 4.33
|
5.34 ± 7.28
|
0.006
|
1.66 ± 2.83
|
3.95 ± 5.59
|
0.038
|
|
V70 (%)
|
0.08 ± 0.31
|
0.44 ± 2.13
|
0.099
|
0.07 ± 0.24
|
0.05 ± 0.27
|
0.785
|
- Abbreviations: DVH dose–volume histograms; AAT acute anal toxicity; NAAT no-acute anal toxicity; Dmax maximum dose; Dmean mean dose; V10–V70 percentage of anal canal volume receiving more than 10–70 Gy
