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Table 2 Univariate analysis of DVH parameters related to AAT

From: Dose-volume analysis of predictors for acute anal toxicity after radiotherapy in prostate cancer patients

 

Training group (N = 248 cases)

Validation group (N = 99 cases)

Variables

NAAT (Mean ± SD)

AAT (Mean ± SD)

P

NAAT (Mean ± SD)

AAT (Mean ± SD)

P

Prescribed Dose (Gy)

67.04 ± 5.02

67.33 ± 5.77

0.672

69.12 ± 4.65

67.35 ± 3.96

0.073

Volume of anal canal (cm3)

9.43 ± 4.02

10.02 ± 3.60

0.232

9.33 ± 3.51

8.00 ± 3.17

0.080

Anal canal Dmax (Gy)

59.51 ± 12.95

63.22 ± 9.65

0.018

54.47 ± 13.83

58.40 ± 11.13

0.169

Anal canal Dmean (Gy)

26.04 ± 12.60

30.25 ± 9.71

0.010

22.51 ± 9.61

29.43 ± 11.52

0.005

V10 (%)

75.61 ± 22.45

84.48 ± 18.89

0.002

67.82 ± 22.35

85.52 ± 18.06

0.001

V20 (%)

58.41 ± 26.62

72.62 ± 25.59

< 0.001

49.71 ± 29.09

74.24 ± 23.84

< 0.001

V30 (%)

37.81 ± 24.32

52.08 ± 26.91

< 0.001

30.65 ± 27.74

49.85 ± 30.98

0.006

V40 (%)

19.31 ± 16.18

27.30 ± 20.44

0.001

13.75 ± 14.98

27.46 ± 25.60

0.009

V50 (%)

8.81 ± 9.09

13.40 ± 13.01

0.002

5.22 ± 6.40

12.83 ± 15.38

0.011

V60 (%)

3.16 ± 4.33

5.34 ± 7.28

0.006

1.66 ± 2.83

3.95 ± 5.59

0.038

V70 (%)

0.08 ± 0.31

0.44 ± 2.13

0.099

0.07 ± 0.24

0.05 ± 0.27

0.785

  1. Abbreviations: DVH dose–volume histograms; AAT acute anal toxicity; NAAT no-acute anal toxicity; Dmax maximum dose; Dmean mean dose; V10–V70 percentage of anal canal volume receiving more than 10–70 Gy