Fig. 7
From: Clinical impact of removing respiratory motion during liver SABR
Comparison of TCP increase due to motion management (MM) for 3 and 5 fraction schedules. TCP is defined as the absolute increase in 24-month local control rate. Part (a) shows the prescribed BEDs (for the ITV-based plan) for the 3 and 5 fraction schedules, plotted alongside the HYTEC TCP model [14]. Part (b) plots the increase in TCP vs the corresponding BED increase for each fractionation schedule; the 3 fraction curve sits lower than the 5 fraction curve due to the decrease in the TCP curve gradient as BED increases. Part (c) shows the results per-patient, demonstrating that for the same anatomical geometry the BED increase ultimately determines which fractionation schedule has the highest increase in TCP, despite the change in the slope of the TCP curve