Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy

Table 2 Clonogenic cell survival LQ fit parameters for photon (α_x and β_x) and helium ion beam (α and β) irradiation using the Renca cells in vitro with corresponding LET_d derived from MC simulation. Data for both experiment A (pristine peaks) and experiment B (SOBPs) are provided

Exp.	α_x [Gy⁻¹]	β_x [Gy⁻²]	(α/β)_x [Gy]	α [Gy⁻¹]	β [Gy⁻²]	LET_d [keV/μm]
A	0.034 (±0.004)	0.018 (±0.001)	1.79	0.039 (±0.013)	0.029 (±0.003)	5.33
A	0.034 (±0.004)	0.018 (±0.001)	1.79	0.094 (±0.012)	0.046 (±0.012)	14.81
B	0.050 (±0.064)	0.023 (±0.014)	2.17	0.076 (±0.083)	0.024 (±0.02)	4.78
B	0.050 (±0.064)	0.023 (±0.014)	2.17	0.150 (±0.071)	0.018 (±0.018)	10.18
B	0.050 (±0.064)	0.023 (±0.014)	2.17	0.201 (±0.048)	0.017 (±0.005)	15.37
B	0.050 (±0.064)	0.023 (±0.014)	2.17	0.305 (±0.144)	0.022 (±0.032)	26.52

ISSN: 1748-717X