Fig. 2
Biologically optimized SOBPs at 2 Gy (RBE) using the data-driven model (DDM) assuming two distinctive tissue types with (α/β)x = 2 Gy (left) and (α/β)x = 10 Gy (right) are displayed as function of the depth in water, plotted against forward calculations with the two biophysical models applied, as well physical dose and LETd distributions (calculated via MC simulation). RBE variation as a function of depth with percent difference DRBE (%∆D-RBE) between planned and forward calculation DRBE for MKM and LEM are displayed in the middle and bottom panel, respectively. The top axis of each figure segments regions of normal tissue (NT) and tumor tissue (T) for a representative clinical treatment