Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial

Table 1 Lasertherapy/photobiomodulation therapy parameters

	Arm A Active Laser group	Arm B Placebo Laser group
Device	He-Ne laser HETSCHL®
Wavelength	Lambda = 658 nm
Power	100 mW
Device condition	ON	OFF
Irradiation time	40 s/cm²	10 s/cm²
Energy density	4 J/cm²	0 J/cm²
Dose administrated	4 J	0 J
Beam area	Intraorally: 1 cm² per application
Pulse parameter	Pulsed < 50 Hz
Anatomical Location	Oral mucositis (Lips - Mouth – Oropharynx) Tumour location was excluded from treated area Maximum area: 10 cm²
Number of treatments	1 session / day, 5 times / week From day of grade II OM occurrence to day of grade II OM resolution
Interval between treatments	1 or 2 days (treatments on radiotherapy days).

ISSN: 1748-717X