Fig. 6
Variation of intratumoral radiosensitivity during BED equivalent fractionated radiation therapy. a Survival of a tumor to different BED-equivalent radiation therapy fractionation schemes at 2.0Gy/day, 2.4Gy/day, 3.0Gy/day, 4.2Gy/day and 7.0Gy/day in 25, 20, 15, 10 and 5 fractions with 5 consecutive treatments per 7-day week. b Intratumoral composition of radiosensitivity for different tumor cell subsets before and after treatments at 2.0Gy/day and 7.0Gy/day in 25 and 5 fractions with 5 consecutive treatments per 7-day week. c Intratumoral distribution of radiosensitivity parameters α and β before and after treatments. The red arrows pointing from right to left represents the evolution of α and β from pre- to post-treatment values. Shift in the mean values of (d) SF2 and (e) α/β ratio within the tumor at the end of BED-equivalent fractionation schemes. Pre-treatment parameters in Eq. (3) were αc = 0.33 Gy− 1 and βc = 0.033 Gy− 2 with σα = 6.5 × 10− 2 Gy− 1 and σβ = 3.5 × 10− 3 Gy− 2 corresponding to the distribution 4 (D4) in Fig. 4c