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Table 4 Univariate and multivariate logistic regression of factors associated with SL during radiation treatment

From: Treatment-duration is related to changes in peripheral lymphocyte counts during definitive radiotherapy for unresectable stage III NSCLC

Characteristic OR (95% CI) P
Univariate analysis
 Sex (female vs male) 0.814 (0.193–3.425) 0.778
 Age (<  65 years vs ≥ 65 years) 1.124 (0.531–2.382) 0.760
 ECOG (0–1 vs 2) 1.439 (0.621–3.334) 0.395
 Underlying respiratory system disease (No versus Yes) 1.586 (0.744–3.383) 0.233
 Smoker (No vs others) 1.275 (0.518–3.139) 0.597
 Induction chemotherapy (No vs Yes) 2.432 (0.963–6.142) 0.06
 Concurrent chemotherapy (No vs Yes) 0.703 (0.308–1.607) 0.404
 Systemic Corticosteroids (No vs Yes)a 0.867 (0.357–2.106) 0.752
 Pre-RT TLCs (cells/μL) 0.998 (0.998–0.999) <  0.001
 GTV (<  22 cm3vs ≥ 22 cm3) 3.867 (1.276–11.714) 0.017
 PTV(<  48 cm3 vs ≥ 48 cm3) 1.478 (0.464–4.706) 0.509
 Mean lung dose (<  1150 cGy vs ≥ 1150 cGy) 2.720 (1.239–5.969) 0.013
 Heart V5 (<  6 vs ≥ 6) 3.704 (1.273–10.777) 0.016
 BED (Gy) 1.026 (0.927–1.137) 0.616
 OTT (LTRT vs STRT) 0.289 (0.117–0.715) 0.007
 IMRT (vs 3DCRT) 1.048 (0.412–2.665) 0.922
 HT (vs 3DCRT) 0.829 (0.353–1.946) 0.667
 Stage IIIB (vs IIIA) 0.900 (0.299–2.712) 0.851
 Stage IIIC (vs IIIA) 0.884 (0.325–2.403) 0.809
Multivariate analysisb
 Pre-RT TLCs (cells/μL) 0.998 (0.997–0.999) <  0.001
 GTV (<  22 cm3vs ≥ 22 cm3) 6.909 (1.729–27.612) 0.006
 Mean lung dose (<  1150 cGy vs ≥ 1150 cGy) 3.633 (1.349–9.787) 0.011
 Treatment duration (LCRT vs SCRT) 0.322 (0.115–0.908) 0.032
  1. Abbreviations: SL severe lymphopenia, OR Odds ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group, RT radiotherapy, TLCs total lymphocyte counts, GTV gross tumor volume, PTV planning target volume, Heart V5 the percentage of total heart volume receiving at least 5 Gy, BED biological effective dose, OTT overall treatment time, LTRT long-term radiotherapy, STRT short-term radiotherapy, 3DCRT 3D conformal radiotherapy, IMRT Intensity modulated radiotherapy, HT Helical Tomotherapy
  2. Note: aequivalent to approximately 60–120 mg of prednisone
  3. bMultivariate analysis includes sex, age, ECOG, induction chemotherapy, Pre-RT TLCs, GTV, mean lung dose, Heart V5, and treatment duration