Table 5 Univariate and multivariate Cox proportional hazards model for overall survival and progression-free survival

Age

0.97 (0.94–1.00)

0.08

0.97 (0.93–1.00)

0.08

0.96 (0.93–1.00)

0.03

0.97 (0.93–1.00)

0.07

BMI

0.99 (0.91–1.07)

0.74

1.05 (0.97–1.13)

0.22

ECOG PS (1 vs. 0)

1.56 (0.83–2.91)

0.17

1.39 (0.74–2.61)

0.30

Clinical T (T3–4 vs. T1–2)

1.06 (0.62–1.80)

0.84

0.93 (0.54–1.58)

0.78

Clinical N (N+ vs. N0)

1.16 (0.50–2.70)

0.72

1.79 (0.72–4.46)

0.21

cTNM stage (III vs. II)

0.89 (0.50–1.56)

0.67

0.68 (0.40–1.17)

0.16

Time from NCRT to surgery

1.01 (0.94–1.09)

0.72

0.98 (0.91–1.06)

0.59

Surgical margin (R1 vs. R0)

2.62 (1.41–4.85)

0.002

3.63 (1.59–8.28)

0.002

4.37 (2.46–7.77)

< 0.001

4.16 (2.11–8.19)

< 0.001

TRG (2/3 vs. 0/1)

3.42 (2.00–5.84)

< 0.001

2.84 (1.50–5.37)

0.001

2.39 (1.44–3.98)

0.001

2.31 (1.30–4.12)

0.004

Gross tumor volume

1.003 (1.000–1.005)

0.09

0.998 (0.994–1.002)

0.27

1.001 (0.998–1.004)

0.44

Target volume

1.00 (1.00–1.00)

0.12

1.00 (1.00–1.00)

0.63

Radiation dose

1.00 (1.00–1.00)

0.16

1.00 (1.00–1.00)

0.32

 V5

1.02 (1.01–1.03)

0.001

1.02 (1.00–1.05)

0.03

1.01 (1.00–1.02)

0.03

1.01 (0.99–1.03)

0.21

 V20

1.07 (1.04–1.11)

< 0.001

1.09 (1.04–1.14)

< 0.001

1.06 (1.02–1.10)

0.002

1.07 (1.03–1.12)

0.001

 Mean heart dose

1.00 (1.00–1.01)

0.03

1.00 (1.00–1.00)

0.55

1.00 (1.00–1.00)

0.41