Characteristics | OS | PFS | ||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Age | 0.97 (0.94–1.00) | 0.08 | 0.97 (0.93–1.00) | 0.08 | 0.96 (0.93–1.00) | 0.03 | 0.97 (0.93–1.00) | 0.07 |
BMI | 0.99 (0.91–1.07) | 0.74 |  |  | 1.05 (0.97–1.13) | 0.22 |  |  |
ECOG PS (1 vs. 0) | 1.56 (0.83–2.91) | 0.17 |  |  | 1.39 (0.74–2.61) | 0.30 |  |  |
Clinical T (T3–4 vs. T1–2) | 1.06 (0.62–1.80) | 0.84 |  |  | 0.93 (0.54–1.58) | 0.78 |  |  |
Clinical N (N+ vs. N0) | 1.16 (0.50–2.70) | 0.72 |  |  | 1.79 (0.72–4.46) | 0.21 |  |  |
cTNM stage (III vs. II) | 0.89 (0.50–1.56) | 0.67 |  |  | 0.68 (0.40–1.17) | 0.16 |  |  |
Time from NCRT to surgery | 1.01 (0.94–1.09) | 0.72 |  |  | 0.98 (0.91–1.06) | 0.59 |  |  |
Surgical margin (R1 vs. R0) | 2.62 (1.41–4.85) | 0.002 | 3.63 (1.59–8.28) | 0.002 | 4.37 (2.46–7.77) | < 0.001 | 4.16 (2.11–8.19) | < 0.001 |
TRG (2/3 vs. 0/1) | 3.42 (2.00–5.84) | < 0.001 | 2.84 (1.50–5.37) | 0.001 | 2.39 (1.44–3.98) | 0.001 | 2.31 (1.30–4.12) | 0.004 |
Gross tumor volume | 1.003 (1.000–1.005) | 0.09 | 0.998 (0.994–1.002) | 0.27 | 1.001 (0.998–1.004) | 0.44 |  |  |
Target volume | 1.00 (1.00–1.00) | 0.12 |  |  | 1.00 (1.00–1.00) | 0.63 |  |  |
Radiation dose | 1.00 (1.00–1.00) | 0.16 |  |  | 1.00 (1.00–1.00) | 0.32 |  |  |
DVH of lunga | ||||||||
 V5 | 1.02 (1.01–1.03) | 0.001 | 1.02 (1.00–1.05) | 0.03 | 1.01 (1.00–1.02) | 0.03 | 1.01 (0.99–1.03) | 0.21 |
 V20 | 1.07 (1.04–1.11) | < 0.001 | 1.09 (1.04–1.14) | < 0.001 | 1.06 (1.02–1.10) | 0.002 | 1.07 (1.03–1.12) | 0.001 |
 Mean heart dose | 1.00 (1.00–1.01) | 0.03 | 1.00 (1.00–1.00) | 0.55 | 1.00 (1.00–1.00) | 0.41 |  |  |